Obesity Research Group, Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, 7489 Trondheim, Norway.
J Clin Endocrinol Metab. 2010 Apr;95(4):1609-16. doi: 10.1210/jc.2009-2082. Epub 2010 Feb 11.
The magnitude of exercise-induced weight loss depends on the extent of compensatory responses. An increase in energy intake is likely to result from changes in the appetite control system toward an orexigenic environment; however, few studies have measured how exercise impacts on both orexigenic and anorexigenic peptides.
The aim of the study was to investigate the effects of medium-term exercise on fasting/postprandial levels of appetite-related hormones and subjective appetite sensations in overweight/obese individuals.
We conducted a longitudinal study in a university research center.
Twenty-two sedentary overweight/obese individuals (age, 36.9 +/- 8.3 yr; body mass index, 31.3 +/- 3.3 kg/m(2)) took part in a 12-wk supervised exercise programme (five times per week, 75% maximal heart rate) and were requested not to change their food intake during the study.
We measured changes in body weight and fasting/postprandial plasma levels of glucose, insulin, total ghrelin, acylated ghrelin (AG), peptide YY, and glucagon-like peptide-1 and feelings of appetite.
Exercise resulted in a significant reduction in body weight and fasting insulin and an increase in AG plasma levels and fasting hunger sensations. A significant reduction in postprandial insulin plasma levels and a tendency toward an increase in the delayed release of glucagon-like peptide-1 (90-180 min) were also observed after exercise, as well as a significant increase (127%) in the suppression of AG postprandially.
Exercise-induced weight loss is associated with physiological and biopsychological changes toward an increased drive to eat in the fasting state. However, this seems to be balanced by an improved satiety response to a meal and improved sensitivity of the appetite control system.
运动引起的体重减轻程度取决于代偿反应的程度。能量摄入的增加可能是由于食欲控制系统向摄食环境的变化所致；然而，很少有研究测量运动对食欲肽和厌食肽的影响。
本研究旨在探讨中期运动对超重/肥胖个体空腹/餐后食欲相关激素水平和主观食欲感觉的影响。
我们在大学研究中心进行了一项纵向研究。
22 名久坐超重/肥胖个体（年龄 36.9 +/- 8.3 岁；体重指数 31.3 +/- 3.3 kg/m(2))参加了为期 12 周的监督运动计划（每周 5 次，最大心率的 75%），并被要求在研究期间不要改变他们的饮食。
我们测量了体重变化和空腹/餐后血糖、胰岛素、总胃饥饿素、酰化胃饥饿素 (AG)、肽 YY 和胰高血糖素样肽-1 以及饥饿感的血浆水平的变化。
运动导致体重、空腹胰岛素显著降低，AG 血浆水平和空腹饥饿感增加。运动后还观察到餐后胰岛素血浆水平显著降低（90-180 分钟时胰高血糖素样肽-1延迟释放趋势增加），AG 餐后抑制作用显著增加（127%）。
运动引起的体重减轻与空腹时进食驱动力增加的生理和心理变化有关。然而，这似乎与餐后饱腹感反应的改善和食欲控制系统敏感性的提高相平衡。
