Schmidt-Ukaj Silvana, Loncaric Igor, Klang Andrea, Spergser Joachim, Häbich Annett-Carolin, Knotek Zdenek
Department for Farm Animals and Veterinary Public Health, Clinic for Avian, Reptile and Fish Medicine, University of Veterinary Medicine Vienna, Vienna, Austria; Clinical Unit of Internal Medicine Small Animals, Department/Clinic for Companion Animals and Horses, University of Veterinary Medicine Vienna, Vienna, Austria.
Vet Dermatol. 2014 Dec;25(6):555-8, e97. doi: 10.1111/vde.12146. Epub 2014 Jun 25.
Description of clinical, microbiological and histopathological findings in a case of deep dermatitis in an inland bearded dragon (Pogona vitticeps) caused by Devriesea agamarum and Chrysosporium guarroi.
A 4-year-old male inland bearded dragon, weighing 497 g, was presented at the clinic because the animal was suffering from dysecdysis and chronic skin lesions. Large numbers of bacilli, cocci and hyphal elements were diagnosed during the microscopic examination of the wound exudate. Microbiological analysis of a skin specimen revealed a moderate growth of Enterococcus sp. and D. agamarum. The condition of the bearded dragon improved with combined therapy consisting of ceftiofur hydrochloride, voriconazole and meloxicam. However, 3 months later recrudescence was observed. This time, Clostridium sp. and Chrysosporium sp. were isolated in large numbers. The bearded dragon was euthanized. Histopathology confirmed a severe granulomatous dermatitis with associated fungal hyphae and a severe granulomatous hepatitis with intralesional hyphae. Chrysosporium guarroi was identified by PCR and sequencing in two organs (skin and liver).
This is the first case of an infection with D. agamarum and C. guarroi in an inland bearded dragon (P. vitticeps). It emphasizes the importance of mycological cultures and specific treatment. Samples of suspected Chrysosporium sp. should be cultured at 30°C for 10-14 days. Early antifungal treatment is necessary to prevent systemic and potentially fatal infection with C. guarroi.
描述一例由阿加马德夫里酵母（Devriesea agamarum）和瓜氏金孢子菌（Chrysosporium guarroi）引起的内陆鬃狮蜥（Pogona vitticeps）深部皮炎的临床、微生物学和组织病理学发现。
一只4岁雄性内陆鬃狮蜥，体重497克，因患蜕皮困难和慢性皮肤损伤被送至诊所。在对伤口渗出液进行显微镜检查时，发现大量杆菌、球菌和菌丝成分。对皮肤样本进行微生物学分析，结果显示肠球菌属（Enterococcus sp.）和阿加马德夫里酵母有中等程度生长。该鬃狮蜥接受了由盐酸头孢噻呋、伏立康唑和美洛昔康组成的联合治疗，病情有所改善。然而，3个月后病情复发。这次，大量分离出梭菌属（Clostridium sp.）和金孢子菌属（Chrysosporium sp.）。该鬃狮蜥被实施安乐死。组织病理学证实为严重的肉芽肿性皮炎，伴有相关真菌菌丝，以及严重的肉芽肿性肝炎，病灶内有菌丝。通过PCR和测序在两个器官（皮肤和肝脏）中鉴定出瓜氏金孢子菌。
这是首例内陆鬃狮蜥（P. vitticeps）感染阿加马德夫里酵母和瓜氏金孢子菌的病例。它强调了真菌培养和特异性治疗的重要性。疑似金孢子菌属的样本应在30°C下培养10 - 14天。早期抗真菌治疗对于预防瓜氏金孢子菌的全身感染及潜在致命感染是必要的。
