Abarca M L, Martorell J, Castellá G, Ramis A, Cabañes F J
Veterinary Mycology Group, Universitat Autònoma de Barcelona, E-08193 Bellaterra, Spain.
Vet Dermatol. 2009 Aug;20(4):295-9. doi: 10.1111/j.1365-3164.2009.00736.x.
A Chrysosporium sp. related to Nannizziopsis vriesii was isolated in pure culture from squames and biopsies of facial lesions in a pet inland bearded dragon (Pogona vitticeps) in Spain. The presence in histological sections of morphologically consistent fungal elements strongly incriminates this fungus as the aetiological agent of infection. Lesions regressed following treatment with oral ketoconazole and topical chlorhexidine and terbinafine until the lizard was lost to follow up 1 month later. The ITS-5.8S rRNA gene of the isolate was sequenced and a search on the GenBank database revealed a high match with the sequences of two Chrysosporium sp. strains recently isolated from green iguanas (Iguana iguana) with dermatomycosis, also in Spain. Phylogenetic analysis of the sequences revealed that all these strains are related to N. vriesii. This is the first report of dermatomycoses caused by a Chrysosporium species related to N. vriesii in a bearded dragon outside North America.
在西班牙，从一只内陆鬃狮蜥（Pogona vitticeps）面部病变的鳞片和活检组织中分离出一种与弗里西拟南芥（Nannizziopsis vriesii）相关的金孢子菌（Chrysosporium sp.）纯培养物。组织学切片中形态一致的真菌成分的存在有力地证明了这种真菌是感染的病原体。口服酮康唑以及局部使用洗必泰和特比萘芬治疗后，病变消退，直到1个月后蜥蜴失去随访。对分离株的ITS-5.8S rRNA基因进行了测序，在GenBank数据库中的搜索显示与最近在西班牙从患有皮肤真菌病的绿鬣蜥（Iguana iguana）中分离出的两种金孢子菌（Chrysosporium sp.）菌株的序列高度匹配。对这些序列的系统发育分析表明，所有这些菌株都与弗里西拟南芥相关。这是北美以外地区鬃狮蜥中由与弗里西拟南芥相关的金孢子菌引起皮肤真菌病的首次报道。
