Bowman Michelle R, Paré Jean A, Sigler Lynne, Naeser John P, Sladky Kurt K, Hanley Chris S, Helmer Peter, Phillips Lynette A, Brower Alexandra, Porter Robert
Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin - Madison, USA.
Med Mycol. 2007 Jun;45(4):371-6. doi: 10.1080/13693780601188610.
The Chrysosporium anamorph of Nannizziopsis vriesii (CANV), a keratinophilic fungus that naturally and experimentally causes severe and often fatal dermatitis in multiple reptile species, was isolated in pure culture from skin samples of three inland bearded dragons (Pogona vitticeps) with deep granulomatous dermatomycosis. The first animal presented with a focal maxillary swelling involving the skin and gingiva. This lizard died while undergoing itraconazole and topical miconazole therapy. The second presented with focally extensive discoloration and thickening of the skin of the ventrum and was euthanized after 10 weeks of itraconazole therapy. A third lizard presented with hyperkeratotic exudative dermatitis on a markedly swollen forelimb. Amputation and itraconazole therapy resulted in a clinical cure. Histopathology of tissue biopsies in all cases demonstrated granulomatous dermatitis with intralesional hyphae morphologically consistent with those produced by the CANV. The second lizard also had granulomatous hepatitis with intralesional hyphae. Evidence in this report suggests that the CANV is the etiologic agent of an emerging condition in captive bearded dragons that has been called 'yellow fungus disease'.
弗里西拟南芥金孢子菌无性型（CANV）是一种嗜角质真菌，在自然和实验条件下可导致多种爬行动物出现严重且往往致命的皮炎。从三只患有深部肉芽肿性皮炎的内陆鬃狮蜥（鬃狮蜥）的皮肤样本中分离出了该真菌的纯培养物。第一只动物出现了累及皮肤和牙龈的上颌局部肿胀。这只蜥蜴在接受伊曲康唑和局部咪康唑治疗时死亡。第二只动物出现了腹部皮肤局部广泛变色和增厚的情况，在接受伊曲康唑治疗10周后实施了安乐死。第三只蜥蜴的一只明显肿胀的前肢出现了角化过度性渗出性皮炎。截肢和伊曲康唑治疗导致了临床治愈。所有病例的组织活检组织病理学均显示为肉芽肿性皮炎，病灶内的菌丝在形态上与CANV产生的菌丝一致。第二只蜥蜴还患有肉芽肿性肝炎，病灶内有菌丝。本报告中的证据表明，CANV是圈养鬃狮蜥中一种新出现疾病的病原体，该疾病被称为“黄真菌病”。
