款冬中的倍半萜类化合物及其对一氧化氮生成的抑制作用。
Sesquiterpenoids from Tussilago farfara and their inhibitory effects on nitric oxide production.
作者信息
Qin Zhi-Bin, Zhang Jing, Wu Xing-De, He Juan, Ding Lin-Fen, Peng Li-Yan, Li Xing-Yao, Li Yan, Deng Liang, Guo Ya-Dong, Zhao Qin-Shi
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, People's Republic of China.
School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, People's Republic of China.
出版信息
Planta Med. 2014 Jun;80(8-9):703-9. doi: 10.1055/s-0034-1368567. Epub 2014 Jun 25.
Tussilagone (TSL) and its allied sesquiterpenoids were considered as the main active principles of the flower buds of Tussilago farfara, which has been widely used in China as an antitussive herbal medicine. Six new bisabolane-type sesquiterpenoids, tussfararins A-F (1-6), along with 12 known sesquiterpenoids, were isolated from the flower buds of T. farfara. Structures of the new compounds were elucidated by extensive spectroscopic analysis. The biological analysis showed that compounds 1, 3, 6, and 7 inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells with IC50 values of 13.6-24.4 µM.
款冬酮（TSL）及其相关倍半萜被认为是款冬花的主要活性成分，在中国，款冬花作为一种镇咳草药被广泛使用。从款冬花中分离出了6个新的愈创木烷型倍半萜，款冬法里林A - F（1 - 6），以及12个已知倍半萜。通过广泛的光谱分析阐明了新化合物的结构。生物学分析表明，化合物1、3、6和7在脂多糖（LPS）刺激的RAW 264.7细胞中抑制一氧化氮（NO）的产生，IC50值为13.6 - 24.4 μM。
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