Molnár J, Béládi I, Földes I
Zentralbl Bakteriol Orig A. 1977 Dec;239(4):521-6.
Five phenothiazine derivatives (chlorpromazine, levomepromazine, diethazine, promethazine and chlorpromazine) sulphoxyde were tested for antimycobacterial activity. The growth of Mycobacterium tuberculosis, M. bovis and M. butyricum was inhibited by chlorpromazine practically at identical concentrations. The minimum inhibitory concentrations for M. tuberculosis were: chlorpromazine and levomepromazine, 10 microgram/ml; diethazine and promethazine 20 microgram/ml, whilst chlorpromazine sulphoxyde was ineffective even at a concentration of 100 microgram/ml. Chlorpromazine and promethazine exerted a measurable bactericidal activity on M. tuberculosis at 50 microgram/ml; total destruction of the organism and loss of acid fastness in part of the cells were shown at 300 microgram/ml. Preliminary studies, in mouse experiments phenothiazine derivatives were ineffective.
对五种吩噻嗪衍生物（氯丙嗪、左美丙嗪、二乙嗪、异丙嗪和氯丙嗪亚砜）进行了抗分枝杆菌活性测试。氯丙嗪对结核分枝杆菌、牛分枝杆菌和丁酸分枝杆菌的生长抑制作用几乎在相同浓度下出现。结核分枝杆菌的最低抑菌浓度为：氯丙嗪和左美丙嗪，10微克/毫升；二乙嗪和异丙嗪，20微克/毫升，而氯丙嗪亚砜即使在100微克/毫升的浓度下也无效。氯丙嗪和异丙嗪在50微克/毫升时对结核分枝杆菌具有可测量的杀菌活性；在300微克/毫升时显示出部分细胞的菌体完全破坏和抗酸性丧失。初步研究表明，在小鼠实验中吩噻嗪衍生物无效。
