神经学中的干细胞——当前观点
Stem cells in neurology--current perspectives.
作者信息
Batista Chary Ely Marquez, Mariano Eric Domingos, Marie Suely Kazue Nagahashi, Teixeira Manoel Jacobsen, Morgalla Matthias, Tatagiba Marcos, Li Jun, Lepski Guilherme
机构信息
Departamento de Neurologia, Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, SP, Brazil.
Department of Neurosurgery, Eberhard-Karls University, Tuebingen, Germany.
出版信息
Arq Neuropsiquiatr. 2014 Jun;72(6):457-65. doi: 10.1590/0004-282x20140045.
UNLABELLED
Central nervous system (CNS) restoration is an important clinical challenge and stem cell transplantation has been considered a promising therapeutic option for many neurological diseases.
OBJECTIVE
The present review aims to briefly describe stem cell biology, as well as to outline the clinical application of stem cells in the treatment of diseases of the CNS.
METHOD
Literature review of animal and human clinical experimental trials, using the following key words: "stem cell", "neurogenesis", "Parkinson", "Huntington", "amyotrophic lateral sclerosis", "traumatic brain injury", "spinal cord injury", "ischemic stroke", and "demyelinating diseases".
CONCLUSION
Major recent advances in stem cell research have brought us several steps closer to their effective clinical application, which aims to develop efficient ways of regenerating the damaged CNS.
未标注
中枢神经系统（CNS）修复是一项重要的临床挑战，干细胞移植已被视为许多神经系统疾病的一种有前景的治疗选择。
目的
本综述旨在简要描述干细胞生物学，并概述干细胞在中枢神经系统疾病治疗中的临床应用。
方法
对动物和人类临床试验进行文献综述，使用以下关键词：“干细胞”、“神经发生”、“帕金森病”、“亨廷顿病”、“肌萎缩侧索硬化症”、“创伤性脑损伤”、“脊髓损伤”、“缺血性中风”和“脱髓鞘疾病”。
结论
干细胞研究的近期重大进展使我们在将其有效应用于临床方面又迈进了几步，其目的是开发出有效修复受损中枢神经系统的方法。
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