Alli Nuran, Yorulmaz Ahu
Ankara Numune Research and Training Hospital and Kafkas University School of Medicine , Ankara , Turkey.
Cutan Ocul Toxicol. 2015;34(2):176-7. doi: 10.3109/15569527.2014.918140. Epub 2014 Jun 25.
Isotretinoin (Iso) is the most effective drug against severe nodulocystic acne. As a synthetic oral retinoid, Iso exerts its actions by modulating cell growth and differentiation. Targeting all the pathophysiologic processes in acne development, Iso has been considered to be an unique drug, however it has several side effects. While chelitis, xerosis, ocular sicca, arthralgia, myalgia, headache, hyperlipidemia are the most common side effects, teratogenicity and depressive symptoms are the most concerning ones. In addition, Iso has unusual side effects which have been described for the first time in the literature. Here, we report a remarkable side effect of Iso in a 23-years-old male patient with retinoid dermatitis affecting the external uretral meatus. To our knowledge, only few cases of retinoid dermatitis in the urethral mucosa due to Iso have been reported in the literature so far.
异维A酸（Iso）是治疗重度结节囊肿性痤疮最有效的药物。作为一种合成口服维甲酸，异维A酸通过调节细胞生长和分化发挥作用。异维A酸针对痤疮发生发展的所有病理生理过程，被认为是一种独特的药物，然而它有多种副作用。虽然唇炎、皮肤干燥、眼干、关节痛、肌痛、头痛、高脂血症是最常见的副作用，但致畸性和抑郁症状是最令人担忧的。此外，异维A酸还有一些文献首次描述的不寻常副作用。在此，我们报告一名23岁男性患者因异维A酸导致的类维生素A皮炎累及尿道外口的显著副作用。据我们所知，迄今为止，文献中仅报道了少数因异维A酸导致尿道黏膜类维生素A皮炎的病例。
