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肌肉注射双氯芬酸后出现上肢坏疽：一种罕见的副作用。

Upper limb gangrene following intramuscular diclofenac: a rare side effect.

作者信息

Hajong Ranendra

机构信息

Department of Surgery, NEIGRIHMS, Shillong, India

出版信息

J Surg Case Rep. 2013 Feb 15;2013(2):rjs039. doi: 10.1093/jscr/rjs039.

DOI:10.1093/jscr/rjs039
PMID:24964408
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3789631/
Abstract

Diclofenac is a very commonly used analgesic medication. Diclofenac is a non-steroidal anti-inflammatory drug and acts by inhibiting COX (cyclo-oxygenase) 1 and 2. It has both analgesic and anti-pyretic effects. It can be administered both orally and parentarelly. Among the many side effects of diclofencac, extensive ganrene of the extremities is never reported as one of the probable complications. Extensive PubMed and other literature searches did not reveal any previously reported case reports, hence the reporting of this case.

摘要

双氯芬酸是一种非常常用的止痛药物。双氯芬酸是一种非甾体抗炎药，通过抑制环氧化酶（COX）1和2发挥作用。它具有止痛和解热作用。它可以口服给药，也可以胃肠外给药。在双氯芬酸的众多副作用中，从未有报道称肢体广泛坏疽是可能的并发症之一。广泛检索PubMed及其他文献未发现任何先前报道的病例报告，因此报告了本病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b181/3789631/a2b3f43bfbcd/rjs03901.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b181/3789631/a2b3f43bfbcd/rjs03901.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b181/3789631/a2b3f43bfbcd/rjs03901.jpg

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A misplaced intramuscular injection and limb-threatening ischemia.

本文引用的文献

1
Nicolau Syndrome: three cases and review.尼科劳综合征：三例报告及文献复习
Int J Dermatol. 2006 Nov;45(11):1326-8. doi: 10.1111/j.1365-4632.2006.02674.x.
2
Nicolau syndrome following intramuscular diclofenac administration: a case report.肌肉注射双氯芬酸后发生的尼科劳综合征：一例报告。
J Orthop Surg (Hong Kong). 2006 Apr;14(1):104-7. doi: 10.1177/230949900601400123.
3
Five cases of livedo-like dermatitis (Nicolau's syndrome) due to bismuth salts and various other non-steroidal anti-inflammatory drugs.五例由铋盐及其他多种非甾体抗炎药引起的类青斑样皮炎（尼科劳综合征）。
一次误行的肌肉注射与危及肢体的缺血。
J Family Med Prim Care. 2017 Jul-Sep;6(3):680-682. doi: 10.4103/2249-4863.222058.
J Eur Acad Dermatol Venereol. 2001 Nov;15(6):585-8. doi: 10.1046/j.1468-3083.2001.00320.x.
4
Embolia cutis medicamentosa.
Int J Dermatol. 1997 Mar;36(3):197. doi: 10.1046/j.1365-4362.1997.00233.x.
5
What syndrome is this? Nicolau syndrome.这是什么综合征？尼科劳综合征。
Pediatr Dermatol. 1995 Jun;12(2):187-90. doi: 10.1111/j.1525-1470.1995.tb00151.x.