Giovannetti M, Machado M A, Borrelli Júnior M, Ikejiri C I, Alonso N, Branco P D
Disciplina de Cirurgia do Trauma, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo.
Rev Hosp Clin Fac Med Sao Paulo. 1993 Jan-Feb;48(1):39-42.
Diclofenac sodium is a non-steroidal anti-inflammatory widely used drug both in the treatment of the rheumatic diseases and as analgesic. The fact that is a potent analgesic spread its use to almost all fields in medicine, increasing the reports of adverse effects associated with it. The main complications reported are gastrointestinal, dermatological and of the central nervous system. The authors present seven cases that developed tissue necrosis as a result of the intramuscular injection of diclofenac sodium. Because of the low incidence or this adverse effect, a review is carried out and the physiopathologic mechanisms likely to be involved are discussed. Our aim is to warn against the indiscriminate intramuscular use of this drug.
双氯芬酸钠是一种非甾体抗炎药，广泛用于治疗风湿性疾病和作为镇痛药。因其强效镇痛作用，其应用几乎扩展到医学的所有领域，与之相关的不良反应报告也日益增多。主要报告的并发症有胃肠道、皮肤和中枢神经系统方面的。作者介绍了7例因肌肉注射双氯芬酸钠而发生组织坏死的病例。鉴于这种不良反应发生率较低，故进行了一项综述，并讨论了可能涉及的病理生理机制。我们的目的是警示不要随意进行该药物的肌肉注射。
