Daniell H B
Department of Cell and Molecular Pharmacology, Medical University of South Carolina, Charleston 29425.
Res Commun Chem Pathol Pharmacol. 1989 Feb;63(2):285-8.
Cardiovascular effects of nitroglycerin, perhexiline and the combination of these two drugs were studied in dogs with myocardial ischemia. Nitroglycerin decreased arterial blood pressure and O2 consumption (MVO2), although heart rate increased. Perhexiline decreased blood pressure, heart rate, MVO2 and modified the tachycardia and the hypotensive actions of nitroglycerin without altering the ability of nitroglycerin to reduce MVO2. These data show that the pharmacologic actions of nitroglycerin in the treatment of ischemic heart disease are enhanced when given in combination with perhexiline or similar calcium antagonists.
在患有心肌缺血的犬中研究了硝酸甘油、哌克昔林以及这两种药物联合使用的心血管效应。硝酸甘油降低动脉血压和氧耗量（MVO2），尽管心率增加。哌克昔林降低血压、心率和MVO2，并改变了硝酸甘油的心动过速和降压作用，但不改变硝酸甘油降低MVO2的能力。这些数据表明，硝酸甘油与哌克昔林或类似的钙拮抗剂联合使用时，其在治疗缺血性心脏病中的药理作用会增强。
