Fournier Stephane, Beggah Ahmed T, Cook Stéphane, Muller Olivier
Rev Med Suisse. 2014 May 28;10(432):1204, 1206-9.
Myocardial infarction is one of the most important causes of mortality and its incidence exhibits a significant circadian pattern with a peak of maximum frequency between 10 am and 11 am. Furthermore, myocardial infarction size and related mortality rate also undergo a variation over 24 hours. Recent publications have shown greatest myocardial injury when symptoms onsets are around midnight and this was independent of ischemic time and quality of care. These data were corroborated by studies using experimental models that unravel correlation between myocardial infarction's size and genes involved in circadian rhythm the link between circadian biology and pathophysiology of ischemia provides a new era of cardiovascular research and in addition new potential therapeutic targets to prevent myocardial ischemic burden.
心肌梗死是最重要的死亡原因之一，其发病率呈现出显著的昼夜节律模式，最高频率峰值出现在上午10点至11点之间。此外，心肌梗死面积和相关死亡率在24小时内也会发生变化。最近的出版物表明，当症状在午夜左右发作时，心肌损伤最为严重，这与缺血时间和护理质量无关。使用实验模型的研究证实了这些数据，这些研究揭示了心肌梗死大小与参与昼夜节律的基因之间的相关性。昼夜生物学与缺血病理生理学之间的联系为心血管研究开创了一个新时代，此外还提供了预防心肌缺血负担的新潜在治疗靶点。
