He Bing, Lin Jia, Cao Lei, Wang Hongge, Rao Juan, Liu Yingwen, Zhang Zhi
Wei Sheng Yan Jiu. 2014 May;43(3):393-6, 418.
To investigate the association of Ile462Val polymorphisms of cytochrome P450 1A1 (CYP1A1) gene with small cell lung cancer susceptibility.
A case-control study was done in 275 patients with small cell lung cancer and 406 control subjects. Genotypes of CYP1A1 Ile462Val were determined by polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP). Logistic regression analysis was performed to estimate odd ratios (ORs) and 95% confidence intervals (95% CI) associated with genetic variants of CYP1A1.
A case-control analysis showed ORs of 0.65 (95% CI 0.48 - 0.91) and 0.60 (95% CI 0.32 - 0.97) for small cell lung cancer in the CYP1A1 462 Ile/Val and 462 Val/Val genotype carriers respectively, compared with 462 Ile/Ile carriers. When stratified by smoking status, the ORs of 462 Ile/Val or Val/Val genotype for nonsmokers and smokers were 0.99 (95% CI 0.62 - 1.51) and 0.42 (95% CI 0.26 - 0.65), respectively. Furthermore, for light and heavy smokers, the ORs of 462 Ile/ Val or Val/Val genotype were 0.42 (95% CI 0.21 - 0.85) and 0.44 (95% CI 0.24 - 0.82), respectively.
CYP1A1 Ile462Val polymorphisms may contribute to the decreased susceptibility of small cell lung cancer.
研究细胞色素P450 1A1（CYP1A1）基因Ile462Val多态性与小细胞肺癌易感性的关系。
对275例小细胞肺癌患者和406例对照者进行病例对照研究。采用基于聚合酶链反应的限制性片段长度多态性（PCR-RFLP）方法测定CYP1A1 Ile462Val基因型。进行逻辑回归分析以估计与CYP1A1基因变异相关的比值比（OR）和95%置信区间（95%CI）。
病例对照分析显示，与462 Ile/Ile基因型携带者相比，CYP1A1 462 Ile/Val和462 Val/Val基因型携带者患小细胞肺癌的OR分别为0.65（95%CI 0.48 - 0.91）和0.60（95%CI 0.32 - 0.97）。按吸烟状况分层后，非吸烟者和吸烟者中462 Ile/Val或Val/Val基因型的OR分别为0.99（95%CI 0.62 - 1.51）和0.42（95%CI 0.26 - 0.65）。此外，轻度和重度吸烟者中462 Ile/Val或Val/Val基因型的OR分别为0.42（95%CI 0.21 - 0.85）和0.44（95%CI 0.24 - 0.82）。
CYP1A1 Ile462Val多态性可能导致小细胞肺癌易感性降低。
