CYP1A1基因Ile462Val多态性与子宫内膜癌风险之间无关联：一项荟萃分析。

Lack of association between the CYP1A1 Ile462Val polymorphism and endometrial cancer risk: a meta-analysis.

作者信息

Wang Xi-Wen, Zhong Tian-Yu, Xiong Yun-Hui, Lin Hai-Bo, Liu Qing-Yi

机构信息

Bao'an Maternal and Child Health Hospital, Shenzhen, China.

出版信息

Asian Pac J Cancer Prev. 2012;13(8):3717-21. doi: 10.7314/apjcp.2012.13.8.3717.

DOI:10.7314/apjcp.2012.13.8.3717

PMID:23098461

Abstract

PURPOSE

Any association between the CYP1A1 Ile462Val polymorphism and endometrial cancer risk remains inconclusive. For a more precise estimate, we performed the present meta-analysis.

METHODS

PUBMED, OVID and EMBASE were searched for the studies which met inclusion criteria. Data in all eligible studies were evaluated and extracted by two authors independently. The meta-analysis estimated pooled odds ratio (OR) with 95% confidence interval (CI) for endometrial cancer risk attributable to the CYP1A1 Ile462Val polymorphism.

RESULTS

A total of 7 studies were included in this meta-analysis. The results indicated no association between endometrial cancer risk and the CYP1A1 Ile462Val polymorphism (for Val vs Ile allele model [OR 1.09, 95% CI 0.73-1.62]; for Val.Val vs Ile.Ile genotype model [OR 1.54, 95% CI 0.56-4.23]; for (Ile.Val + Val.Val) vs Ile.Ile genotype model [OR 1.08, 95% CI 0.71-1.63]; for Val.Val vs (Ile.Ile + Ile.Val) genotype model [OR 1.46, 95% CI 0.53-4.04]).

CONCLUSIONS

This meta-analysis suggests that there is no association between endometrial cancer risk and the CYP1A1 Ile462Val polymorphism.

摘要

目的

细胞色素P450 1A1（CYP1A1）基因Ile462Val多态性与子宫内膜癌风险之间的任何关联仍无定论。为了进行更精确的评估，我们进行了本次荟萃分析。

方法

检索了PUBMED、OVID和EMBASE中符合纳入标准的研究。所有符合条件的研究数据由两位作者独立评估和提取。荟萃分析估计了CYP1A1基因Ile462Val多态性导致子宫内膜癌风险的合并比值比（OR）及其95%置信区间（CI）。

结果

本次荟萃分析共纳入7项研究。结果表明，子宫内膜癌风险与CYP1A1基因Ile462Val多态性之间无关联（Val与Ile等位基因模型[OR 1.09，95%CI 0.73 - 1.62]；Val.Val与Ile.Ile基因型模型[OR 1.54，95%CI 0.56 - 4.23]；（Ile.Val + Val.Val）与Ile.Ile基因型模型[OR 1.08，95%CI 0.71 - 1.63]；Val.Val与（Ile.Ile + Ile.Val）基因型模型[OR 1.46，95%CI 0.53 - 4.04]）。