老挝献血者中的红细胞同种抗体。

Red cell alloantibodies in Lao blood donors.

作者信息

Keokhamphoui Chirapha, Urwijitaroon Yupa, Kongphaly Douangchanh, Thammavong Te

出版信息

Southeast Asian J Trop Med Public Health. 2014 Jan;45(1):194-7.

Abstract

Data of the prevalence of red cell alloantibodies in blood donors will assist in improving safe blood supply for patients needing transfusion. The purpose of this study was to determine prevalence of red cell alloantibodies in Lao blood donors. Antibody screening and identification by multiple phase indirect antiglobulin standard tube assay were performed in serum samples from 1,181 blood donor individuals following routine work at the Lao Red Cross National Blood Transfusion Center. The overall prevalence of alloantibodies was 3.90%. All of the antibodies found were naturally occurring antibodies. Anti-P1 was the most common with a frequency of 1.95% followed by anti-Le(a), anti-Le(b), anti-Le(a+b), anti-M, anti-P1 plus anti-Le(a), anti-P1 plus anti-Le(a+b) with the prevalence of 0.59%, 0.42%, 0.42%, 0.17%, and 0.08%, respectively. This is the first report about prevalence of red cell alloantibodies among Lao blood donors. The information obtained from this study will be useful for safe blood transfusion and preparation of in house antisera.

摘要

献血者中红细胞同种抗体的流行数据将有助于改善需要输血患者的安全血液供应。本研究的目的是确定老挝献血者中红细胞同种抗体的流行情况。在老挝红十字会国家输血中心按照常规工作，对1181名献血者的血清样本进行多阶段间接抗球蛋白标准试管试验，以进行抗体筛查和鉴定。同种抗体的总体流行率为3.90%。发现的所有抗体均为天然抗体。抗-P1最为常见，频率为1.95%，其次是抗-Le(a)、抗-Le(b)、抗-Le(a+b)、抗-M、抗-P1加抗-Le(a)、抗-P1加抗-Le(a+b)，流行率分别为0.59%、0.42%、0.42%、0.17%和0.08%。这是关于老挝献血者中红细胞同种抗体流行情况的首次报告。从本研究中获得的信息将有助于安全输血和自制抗血清的制备。