Pahuja Sangeeta, Kushwaha Shivani, Sethi Neha, Pujani Meenu, Jain Manjula
Lady Hardinge Medical College, New Delhi, India.
Hematology. 2012 Sep;17(5):302-5. doi: 10.1179/1607845412Y.0000000020.
To assess the prevalence of the anti-red blood cell antibodies in the donor population of Delhi.
This prospective study was conducted in Regional Blood Transfusion Centre (RBTC), Lady Hardinge Medical College (LHMC) and associated hospitals from March 2010 to March 2011. Antibody screening of all donor serum/plasma was performed as routine immunohaematological procedure. Any positive sera were further investigated to identify the specificity of irregular erythrocyte antibody by commercially available red cell panel (ID-Dia Panel, Diamed-ID Microtyping System). The titres and thermal amplitude of the identified antibodies were evaluated.
A total of 7756 donors were screened, of which 7648 donors were males (98.6%) and 108 were females (1.4%). The maximum number of donors belonged to age group of 26-30 years. A total of four donors showed presence of alloantibodies in their serum (0.05%). On antibody identification, two of them were anti-C, one was anti-Lewis(a) antibody and one was autoantibody.
This study was conducted to highlight the significance of detecting irregular erythrocyte antibodies in healthy donors.
评估德里献血人群中抗红细胞抗体的流行情况。
这项前瞻性研究于2010年3月至2011年3月在哈丁夫人医学院区域输血中心（RBTC）及其附属医院开展。对所有献血者的血清/血浆进行抗体筛查，这是常规免疫血液学检查程序。任何阳性血清都要进一步检测，通过市售红细胞谱（ID-Dia Panel，Diamed-ID微量定型系统）来鉴定不规则红细胞抗体的特异性。对鉴定出的抗体的效价和热振幅进行评估。
共筛查了7756名献血者，其中7648名男性（98.6%），108名女性（1.4%）。献血者人数最多的年龄组为26 - 30岁。共有4名献血者血清中存在同种抗体（0.05%）。经抗体鉴定，其中2例为抗-C，1例为抗-Lewis(a)抗体，1例为自身抗体。
开展本研究是为了强调在健康献血者中检测不规则红细胞抗体的重要性。
