评估四价脑膜炎球菌结合疫苗和多糖疫苗在英国成年人中免疫原性的随机临床试验。
Randomized clinical trial to evaluate the immunogenicity of quadrivalent meningococcal conjugate and polysaccharide vaccines in adults in the United kingdom.
作者信息
Ramasamy Maheshi N, Clutterbuck Elizabeth A, Haworth Kathryn, Bowman Jaclyn, Omar Omar, Thompson Amber J, Blanchard-Rohner Geraldine, Yu Ly-Mee, Snape Matthew D, Pollard Andrew J
机构信息
Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom
Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom.
出版信息
Clin Vaccine Immunol. 2014 Aug;21(8):1164-8. doi: 10.1128/CVI.00099-14. Epub 2014 Jun 25.
Abstract
Meningococcal conjugate vaccines are today successfully deployed in universal programs for children and adolescents in different geographic regions to control meningitis and septicemia. However, in adults, the advantages of these conjugates over the older polysaccharide vaccines are less clear. In this randomized clinical trial, we demonstrated that both conjugate and polysaccharide quadrivalent meningococcal vaccines elicit protective antibody responses in adults aged 18 to 70. (This study has been registered at www.clinicaltrials.gov under registration no. NCT00901940.).
摘要
目前，脑膜炎球菌结合疫苗已成功应用于不同地理区域针对儿童和青少年的普及计划中，以控制脑膜炎和败血症。然而，在成年人中，这些结合疫苗相对于较旧的多糖疫苗的优势尚不太明确。在这项随机临床试验中，我们证明了结合疫苗和多糖四价脑膜炎球菌疫苗均可在18至70岁的成年人中引发保护性抗体反应。（本研究已在www.clinicaltrials.gov上注册，注册号为NCT00901940。）
相似文献
1
Randomized clinical trial to evaluate the immunogenicity of quadrivalent meningococcal conjugate and polysaccharide vaccines in adults in the United kingdom.评估四价脑膜炎球菌结合疫苗和多糖疫苗在英国成年人中免疫原性的随机临床试验。
Clin Vaccine Immunol. 2014 Aug;21(8):1164-8. doi: 10.1128/CVI.00099-14. Epub 2014 Jun 25.
2
Primary and booster mucosal immune responses to meningococcal group A and C conjugate and polysaccharide vaccines administered to university students in the United Kingdom.对在英国大学生中接种的A群和C群脑膜炎球菌结合疫苗及多糖疫苗的初次和加强黏膜免疫反应
Infect Immun. 2001 Jul;69(7):4337-41. doi: 10.1128/IAI.69.7.4337-4341.2001.
3
Safety and immunogenicity of a booster dose of meningococcal (groups A, C, W, and Y) polysaccharide diphtheria toxoid conjugate vaccine.一剂次脑膜炎球菌（A、C、W和Y群）多糖白喉类毒素结合疫苗的安全性和免疫原性
Vaccine. 2016 Oct 17;34(44):5273-5278. doi: 10.1016/j.vaccine.2016.09.003. Epub 2016 Sep 15.
4
Vaccines for the prevention of meningococcal disease in children.用于预防儿童脑膜炎球菌病的疫苗。
Semin Pediatr Infect Dis. 2002 Jul;13(3):182-9. doi: 10.1053/spid.2002.125861.
5
Development of new vaccines against meningococcal disease.新型抗脑膜炎球菌病疫苗的研发
Arzneimittelforschung. 2003;53(12):805-13. doi: 10.1055/s-0031-1299834.
6
[Active immunization against serogroup B Neisseria meningitidis].[针对B群脑膜炎奈瑟菌的主动免疫]
Enferm Infecc Microbiol Clin. 2003 Nov;21(9):513-9. doi: 10.1016/s0213-005x(03)72998-x.
7
Structure of a protective epitope reveals the importance of acetylation of serogroup A capsular polysaccharide.一种保护性表位的结构揭示了A群荚膜多糖乙酰化的重要性。
Proc Natl Acad Sci U S A. 2020 Nov 24;117(47):29795-29802. doi: 10.1073/pnas.2011385117. Epub 2020 Nov 6.
8
Antibody responses to meningococcal (groups A, C, Y and W135) polysaccharide diphtheria toxoid conjugate vaccine in children who previously received meningococcal C conjugate vaccine.既往接种过脑膜炎球菌C结合疫苗的儿童对脑膜炎球菌（A、C、Y和W135群）多糖-白喉类毒素结合疫苗的抗体反应。
Vaccine. 2006 Mar 24;24(14):2544-9. doi: 10.1016/j.vaccine.2005.12.018. Epub 2005 Dec 27.
9
Quadrivalent meningococcal vaccines: hyporesponsiveness as an important consideration when choosing between the use of conjugate vaccine or polysaccharide vaccine.四价脑膜炎球菌疫苗：在选择使用结合疫苗还是多糖疫苗时，低反应性是一个重要的考虑因素。
Travel Med Infect Dis. 2010 Jan;8(1):47-50. doi: 10.1016/j.tmaid.2009.12.001. Epub 2010 Jan 8.
10
Mucosal immune responses to meningococcal group C conjugate and group A and C polysaccharide vaccines in adolescents.青少年对C群脑膜炎球菌结合疫苗以及A群和C群多糖疫苗的黏膜免疫反应。
Infect Immun. 2000 May;68(5):2692-7. doi: 10.1128/IAI.68.5.2692-2697.2000.
引用本文的文献
1
Immunogenicity and safety of MenACWY-TT, a quadrivalent meningococcal tetanus toxoid conjugate vaccine recently licensed in the United States for individuals ≥2 years of age.在美国新近获批用于≥2 岁人群的四价脑膜炎球菌结合疫苗 MenACWY-TT 的免疫原性和安全性。
Hum Vaccin Immunother. 2022 Nov 30;18(6):2099142. doi: 10.1080/21645515.2022.2099142. Epub 2022 Aug 10.
2
Alternative Complement Pathway Inhibition Does Not Abrogate Meningococcal Killing by Serum of Vaccinated Individuals.替代补体途径抑制不能消除疫苗接种个体血清对脑膜炎奈瑟菌的杀伤作用。
Front Immunol. 2021 Oct 8;12:747594. doi: 10.3389/fimmu.2021.747594. eCollection 2021.
3
A Decade of Fighting Invasive Meningococcal Disease: A Narrative Review of Clinical and Real-World Experience with the MenACWY-CRM Conjugate Vaccine.抗击侵袭性脑膜炎球菌病的十年：关于MenACWY-CRM结合疫苗临床及实际应用经验的叙述性综述
Infect Dis Ther. 2022 Apr;11(2):639-655. doi: 10.1007/s40121-021-00519-2.
4
Study of the Immune Response in the Elderly: Is It Necessary to Develop a Vaccine against for the Aged?老年人免疫反应的研究：是否有必要研发针对老年人的疫苗？
J Aging Res. 2019 Aug 22;2019:9287121. doi: 10.1155/2019/9287121. eCollection 2019.
5
Novel Intervention in the Aging Population: A Primary Meningococcal Vaccine Inducing Protective IgM Responses in Middle-Aged Adults.老年人群中的新型干预措施：一种在中年成年人中诱导保护性IgM反应的脑膜炎球菌疫苗。
Front Immunol. 2017 Jul 19;8:817. doi: 10.3389/fimmu.2017.00817. eCollection 2017.
6
High-dimensional assessment of B-cell responses to quadrivalent meningococcal conjugate and plain polysaccharide vaccine.B细胞对四价脑膜炎球菌结合疫苗和平价多糖疫苗反应的高维评估
Genome Med. 2017 Jan 30;9(1):11. doi: 10.1186/s13073-017-0400-x.
7
BCR repertoire sequencing: different patterns of B-cell activation after two Meningococcal vaccines.BCR 重排测序：两种脑膜炎球菌疫苗接种后 B 细胞活化的不同模式
Immunol Cell Biol. 2015 Nov;93(10):885-95. doi: 10.1038/icb.2015.57. Epub 2015 May 15.
本文引用的文献
1
The immunogenicity and safety of an investigational meningococcal serogroups A, C, W-135, Y tetanus toxoid conjugate vaccine (ACWY-TT) compared with a licensed meningococcal tetravalent polysaccharide vaccine: a randomized, controlled non-inferiority study.一项探索性的 A、C、W-135、Y 群脑膜炎奈瑟球菌破伤风类毒素结合疫苗（ACWY-TT）与已上市的脑膜炎奈瑟球菌四价多糖疫苗的免疫原性和安全性比较的随机、对照、非劣效性研究。
Hum Vaccin Immunother. 2012 Jul;8(7):873-80. doi: 10.4161/hv.20211. Epub 2012 Apr 9.
2
Seroprevalence of serum bactericidal antibodies against group W135 and Y meningococci in England in 2009.2009年英格兰针对W135群和Y群脑膜炎球菌的血清杀菌抗体血清阳性率。
Clin Vaccine Immunol. 2012 Feb;19(2):219-22. doi: 10.1128/CVI.05515-11. Epub 2011 Dec 21.
3
The nature of an in vivo anti-capsular polysaccharide response is markedly influenced by the composition and/or architecture of the bacterial subcapsular domain.荚膜多糖的体内抗荚膜多糖反应的性质受细菌荚膜下域的组成和/或结构的显著影响。
J Immunol. 2012 Jan 15;188(2):569-77. doi: 10.4049/jimmunol.1101446. Epub 2011 Dec 7.
4
Safety and immunogenicity of a tetravalent meningococcal serogroups A, C, W-135 and Y conjugate vaccine in adolescents and adults.一种A、C、W-135和Y群四价脑膜炎球菌结合疫苗在青少年和成人中的安全性和免疫原性。
Hum Vaccin. 2011 Feb;7(2):239-47. doi: 10.4161/hv.7.2.14068. Epub 2011 Feb 1.
5
Meningococcal carriage by age: a systematic review and meta-analysis.年龄与脑膜炎奈瑟菌带菌率：系统评价与荟萃分析。
Lancet Infect Dis. 2010 Dec;10(12):853-61. doi: 10.1016/S1473-3099(10)70251-6. Epub 2010 Nov 11.
6
Safety and immunogenicity of an investigational quadrivalent meningococcal CRM(197) conjugate vaccine, MenACWY-CRM, compared with licensed vaccines in adults in Latin America.在拉丁美洲成年人中，与已上市疫苗相比，一种新型四价脑膜炎球菌 CRM(197)结合疫苗 MenACWY-CRM 的安全性和免疫原性。
Int J Infect Dis. 2010 Oct;14(10):e868-75. doi: 10.1016/j.ijid.2010.03.017. Epub 2010 Jul 22.
7
The early kinetics of circulating pneumococcal-specific memory B cells following pneumococcal conjugate and plain polysaccharide vaccines in the elderly.老年人接种肺炎球菌结合疫苗和普通多糖疫苗后循环肺炎球菌特异性记忆 B 细胞的早期动力学。
Vaccine. 2010 Jul 5;28(30):4763-70. doi: 10.1016/j.vaccine.2010.04.103. Epub 2010 May 14.
8
Appearance of peripheral blood plasma cells and memory B cells in a primary and secondary immune response in humans.人类初次和再次免疫应答中周边血浆细胞和记忆 B 细胞的出现。
Blood. 2009 Dec 3;114(24):4998-5002. doi: 10.1182/blood-2009-03-211052. Epub 2009 Oct 20.
9
Quadrivalent meningococcal vaccination of adults: phase III comparison of an investigational conjugate vaccine, MenACWY-CRM, with the licensed vaccine, Menactra.成人四价脑膜炎球菌疫苗接种：研究用结合疫苗MenACWY-CRM与已获许可疫苗Menactra的III期比较。
Clin Vaccine Immunol. 2009 Dec;16(12):1810-5. doi: 10.1128/CVI.00207-09. Epub 2009 Oct 7.
10
Human marginal zone B cells.人边缘区B细胞。
Annu Rev Immunol. 2009;27:267-85. doi: 10.1146/annurev.immunol.021908.132607.
Zotero 插件