Guo Guoning, Zhu Guoyan, Sun Wei, Yin Changlin, Ren Xiaobao, Wang Tinggang, Liu Minghua
Department of Emergency, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China.
Cell Biochem Biophys. 2014 Nov;70(2):1427-32. doi: 10.1007/s12013-014-0076-4.
Acute mountain sickness (AMS) is the most common high altitude illnesses experienced during rapid ascent to a higher altitude without prior acclimation. It is mainly characterized by a headache which may be accompanied with nausea, vomiting, anorexia, dizziness, lethargy, fatigue, and sleep disturbance. If not diagnosed and treated in a timely manner, AMS can develop into deadly high altitude pulmonary edema or high altitude cerebral edema. In the previous studies of individual variation in susceptibility to AMS, arterial oxygen saturation (SO2) was identified as being associated with AMS. However, other studies have reported no association between AMS and arterial oxygen saturation. In this study, the association between SO2 and AMS was assessed through a meta-analysis of published data. The literature databases PubMed, Web of Science, LWW, Science Direct, and Embase were queried for papers published before 15 April 2014. A fixed-effects model and a random-effects model were applied (Revman 5.0) on the basis of heterogeneity, and the study quality was assessed in duplicate. Twelve studies with 614 AMS patients and 1,025 control subjects were analyzed. There was a significant association with differences in SO2 and the risk of developing AMS. SO2 values are associated with AMS incidence.
急性高原病（AMS）是在未预先适应的情况下快速上升到更高海拔时最常见的高原疾病。它主要表现为头痛，可能伴有恶心、呕吐、食欲不振、头晕、嗜睡、疲劳和睡眠障碍。如果不及时诊断和治疗，AMS可能发展为致命的高原肺水肿或高原脑水肿。在先前关于AMS易感性个体差异的研究中，动脉血氧饱和度（SO2）被确定与AMS有关。然而，其他研究报告称AMS与动脉血氧饱和度之间没有关联。在本研究中，通过对已发表数据的荟萃分析评估了SO2与AMS之间的关联。检索了文献数据库PubMed、Web of Science、LWW、Science Direct和Embase，查找2014年4月15日前发表的论文。根据异质性应用固定效应模型和随机效应模型（Revman 5.0），并对研究质量进行了两次评估。分析了12项研究，其中有614例AMS患者和1025例对照受试者。SO2差异与发生AMS的风险之间存在显著关联。SO2值与AMS发病率相关。
