How Vivien, Hashim Zailina, Ismail Patimah, Omar Dzolkhifli, Said Salmiah Md, Tamrin Shamsul Bahri Mohd
a Faculty of Medicine and Health Sciences, Universiti Putra Malaysia , Selangor , Malaysia.
Arch Environ Occup Health. 2015;70(2):102-9. doi: 10.1080/19338244.2013.823905.
This is a cross-sectional study conducted among paddy farmers to characterize potential risk factors that influence levels of DNA damage from exposure to mixtures of organophosphates. Comet assay was used to determine the level of DNA damage by measuring the comet tail length from the exfoliated buccal mucosa. The result suggests that farmers who chronically exposure to a mixture of organophosphates has at least 2-fold significant increase of DNA damage as compared with control group. Factor analysis and linear regression both suggest that DNA damage reported by farmers may influence individual, occupational, and residential factors and are reported as significant predictor factors, whereas this effect is mainly caused by individual factors among the control group. The findings of the present study suggest that either farmer or control group bear certain extent of genotoxic burden contributed by different risk factors.
这是一项针对稻农开展的横断面研究，旨在确定影响有机磷酸酯混合物暴露所致DNA损伤水平的潜在风险因素。采用彗星试验，通过测量脱落口腔黏膜的彗星尾长来确定DNA损伤水平。结果表明，长期暴露于有机磷酸酯混合物的农民与对照组相比，DNA损伤显著增加至少2倍。因子分析和线性回归均表明，农民报告的DNA损伤可能受个体、职业和居住因素影响，且这些因素被报告为显著预测因素，而在对照组中，这种影响主要由个体因素导致。本研究结果表明，农民组和对照组均承受着不同风险因素带来的一定程度的遗传毒性负担。
