Yang Honghong, Heng Xueyuan, Liang Cuige, Liu Xiaomeng, Du Wenhua, Li Shoujie, Wang Yueli, Dong Qingyu, Li Wenxia, Pan Zhenyu, Gong Qian, Gao Guanqi
Department of Endocrinology, Yishui People's Hospital, Linyi, Shandong Province, China.
Department of Clinical Medicine, Linyi People's Hospital, Linyi, Shandong Province, China.
J Int Med Res. 2014 Aug;42(4):1002-10. doi: 10.1177/0300060514533523. Epub 2014 Jun 25.
To investigate prospectively the insulin dose requirements of Chinese patients with type 2 diabetes mellitus treated with either multiple daily insulin injections (MDI) or continuous subcutaneous insulin infusion (CSII) therapy during a 2-week therapeutic intervention.
Patients with type 2 diabetes mellitus were randomly assigned to MDI or CSII therapy. The effects of the two treatment methods were determined based on blood glucose parameters, total daily insulin dose and rates of hypoglycaemia.
A total of 609 patients were enrolled in the study. Glycaemic goals were achieved after a mean ± SD of 6.90 ± 2.10 and 5.44 ± 2.22 days' treatment in the MDI and CSII groups, respectively. Once stabilized, the mean ± SD total daily insulin doses were 37.12 ± 10.19 IU and 32.58 ± 8.78 IU for the MDI and CSII groups, respectively. Once stabilized, the mean ± SD total basal and bolus doses were 19.46 ± 7.95 IU/day and 17.66 ± 3.53 IU/day for the MDI group, and 22.79 ± 7.55 IU/day and 9.81 ± 2.64 IU/day for the CSII group, respectively. There were significant differences in the total, basal and bolus insulin doses between the two groups.
CSII therapy may be considered as an effective method to achieve good glycaemic control in Chinese patients with type 2 diabetes mellitus.
前瞻性研究在为期2周的治疗干预期间，接受多次皮下注射胰岛素（MDI）或持续皮下胰岛素输注（CSII）治疗的中国2型糖尿病患者的胰岛素剂量需求。
将2型糖尿病患者随机分配至MDI或CSII治疗组。根据血糖参数、每日胰岛素总剂量和低血糖发生率来确定两种治疗方法的效果。
共有609例患者纳入本研究。MDI组和CSII组分别在平均±标准差6.90±2.10天和5.44±2.22天的治疗后达到血糖目标。病情稳定后，MDI组和CSII组的每日胰岛素平均±标准差总剂量分别为37.12±10.19 IU和32.58±8.78 IU。病情稳定后，MDI组的基础胰岛素和追加胰岛素平均±标准差总剂量分别为19.46±7.95 IU/天和17.66±3.53 IU/天，CSII组分别为22.79±7.55 IU/天和9.81±2.64 IU/天。两组之间的胰岛素总剂量、基础剂量和追加剂量存在显著差异。
CSII治疗可被视为在中国2型糖尿病患者中实现良好血糖控制的有效方法。
