Oliver F, Llopis B, Vera C, Domínguez C, Vidal J, Gallego J, Jiménez J F
Actas Urol Esp. 1989 Jan-Feb;13(1):41-3.
A retrospective study of 56 patients (23 primary and 36 relapsing) with superficial vesical carcinoma and treated with transurethral resection and directed chemoprophylaxis was done. Directed chemoprophylaxis is define as a specific type of adjuvant therapy where the drug is determined by a previous study with multivariant analysis of the relapse risk factors of a group of 385 cases, where the chemotherapeutic agent was also a variable. The drug is specified by the data introduced in a microprocessor program. Such chemoprophylactic approach has achieved a marked reduction in the relapse rate and increased the disease-free interval from 8 to 3 and from 70 to 83.5 respectively, with regard to the free drug choice approach.
对56例浅表性膀胱癌患者（23例初发和36例复发）进行了一项回顾性研究，这些患者均接受了经尿道切除术和定向化学预防治疗。定向化学预防被定义为一种特定类型的辅助治疗，其中药物由先前对一组385例病例的复发危险因素进行多变量分析的研究确定，化疗药物也是一个变量。该药物由微处理器程序中输入的数据指定。与自由选择药物的方法相比，这种化学预防方法使复发率显著降低，无病间期分别从8个月延长至3个月，从70个月延长至83.5个月。
