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研究基层医疗中老年(≥50 岁)社区获得性肺炎的负担:希腊克里特岛农村的一项观察性研究。

Studying the burden of community-acquired pneumonia in adults aged ≥50 years in primary health care: an observational study in rural Crete, Greece.

机构信息

Clinic of Social and Family Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece.

Department of Thoracic Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece.

出版信息

NPJ Prim Care Respir Med. 2014 Jun 26;24:14017. doi: 10.1038/npjpcrm.2014.17.

Abstract

BACKGROUND

Community-acquired pneumonia (CAP) is a potentially life-threatening condition that often requires hospitalisation particularly in the elderly population or in patients with comorbidities.

AIMS

The aims of this study were to estimate the CAP frequency and severity in a well-defined primary healthcare setting in rural Crete, to record patient characteristics, their immunisation status and to estimate hospitalisation frequency and determinants.

METHODS

An observational study was designed and implemented in a rural setting within the prefecture of Heraklion in the island of Crete, Greece. Eligible patients were those aged 50 years or above, presenting with CAP based on signs and symptoms and positive X-ray findings.

RESULTS

A total of 124 CAP cases were recorded, 40 of which (32.3%) were hospitalised. Τhe age-standardised CAP incidence was estimated to be 236.7 cases per 100,000 persons aged ≥50 years. Forty-three patients (35.2%) were vaccinated against pneumococcus. The most frequent chronic illnesses were heart disease (64.5%), chronic obstructive pulmonary disease (32.5%), and type 2 diabetes (21%). Hospitalisation determinants included advanced age (≥74 years, Odds ratio (OR) 7.13; P value=0.001; 95% confidence interval (CI), 2.23-22.79), obesity (OR 3.36, P=0.037; 95% CI, 1.08-10.52), ≥40 pack-years of smoking (OR 3.82, P value=0.040; 95% CI, 1.07-18.42), presence of multimorbidity (OR 5.77, P value=0.003; 95% CI, 1.81-18.42) and pneumococcal vaccination (OR 0.29, P value=0.041; 95% CI, 0.09-0.95).

CONCLUSIONS

This study highlighted patient characteristics and aspects of CAP epidemiology in the context of a rural primary care setting in southern Europe where limited data have been published until now.

摘要

背景

社区获得性肺炎(CAP)是一种潜在的危及生命的疾病,特别是在老年人群或合并症患者中,往往需要住院治疗。

目的

本研究旨在评估克里特岛赫拉克勒翁州农村地区一个明确界定的初级保健环境中 CAP 的频率和严重程度,记录患者特征、其免疫状况,并评估住院频率和决定因素。

方法

在希腊克里特岛的赫拉克勒翁州的农村地区设计并实施了一项观察性研究。符合条件的患者为年龄在 50 岁或以上,根据体征和症状以及 X 光检查结果诊断为 CAP。

结果

共记录了 124 例 CAP 病例,其中 40 例(32.3%)住院。年龄标准化的 CAP 发病率估计为每 100,000 名年龄≥50 岁的人中发生 236.7 例。43 名患者(35.2%)接种了肺炎球菌疫苗。最常见的慢性疾病包括心脏病(64.5%)、慢性阻塞性肺疾病(32.5%)和 2 型糖尿病(21%)。住院决定因素包括年龄较大(≥74 岁,优势比(OR)7.13;P 值=0.001;95%置信区间(CI),2.23-22.79)、肥胖(OR 3.36,P=0.037;95%CI,1.08-10.52)、吸烟≥40 包年(OR 3.82,P 值=0.040;95%CI,1.07-18.42)、存在多种合并症(OR 5.77,P 值=0.003;95%CI,1.81-18.42)和肺炎球菌疫苗接种(OR 0.29,P 值=0.041;95%CI,0.09-0.95)。

结论

本研究强调了南欧农村初级保健环境中 CAP 的患者特征和流行病学方面,到目前为止,这方面的数据有限。

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