Oulton M, Rasmusson M G, Yoon R Y, Fraser M
Department of Obstetrics and Gynecology, Dalhousie University, Halifax, Nova Scotia, Canada.
Am J Obstet Gynecol. 1989 Apr;160(4):961-7. doi: 10.1016/0002-9378(89)90317-7.
The effects of cortisol (0.1 mg per dose, administered intraperitoneally to fetal rabbits at 24 to 27 days' gestation), thyrotropin-releasing hormone (40 micrograms/kg per dose administered intravenously to the doe at 24 to 26 days' gestation), or a combination of the two on surfactant pool size (both intracellular and extracellular) at 27 or 28 days' gestation was investigated. Cortisol increased both surfactant pools only when administered on the twenty-fourth or twenty-fifth gestational day. Thyrotropin-releasing hormone, whether administered in single or multiple doses, had no effect on the extracellular pool but increased the intracellular pool; the magnitude of the response (approximately twofold) was similar to that observed with the cortisol response. All combinations of cortisol and thyrotropin-releasing hormone resulted in an increased response over either drug given alone. The greatest response (almost tenfold) resulted from cortisol administration at 24 days' gestation plus thyrotropin-releasing hormone administration at 24+ 25+ 26 days. These data demonstrate differential effects of glucocorticoids and thyrotropin-releasing hormone on developing lung and furthermore show that the timing of their combined treatment may be crucial to achieving maximal response.
研究了皮质醇（每剂0.1毫克，在妊娠24至27天对胎兔进行腹腔注射）、促甲状腺激素释放激素（在妊娠24至26天对母兔静脉注射，每剂40微克/千克）或两者联合使用对妊娠27或28天时表面活性剂池大小（细胞内和细胞外）的影响。仅在妊娠第24天或第25天给予皮质醇时，细胞内和细胞外表面活性剂池均会增加。促甲状腺激素释放激素，无论单次给药还是多次给药，对细胞外表面活性剂池均无影响，但会增加细胞内表面活性剂池；反应幅度（约两倍）与皮质醇反应相似。皮质醇和促甲状腺激素释放激素的所有组合均导致比单独使用任何一种药物时更大的反应。最大反应（几乎十倍）来自于在妊娠第24天给予皮质醇以及在妊娠第24、25和26天给予促甲状腺激素释放激素。这些数据表明糖皮质激素和促甲状腺激素释放激素对发育中的肺有不同影响，并且进一步表明联合治疗的时机对于实现最大反应可能至关重要。
