妊娠期宫颈上皮内瘤变的研究。
A study of cervical intraepithelial neoplasia in pregnancy.
作者信息
Khanuja Esha, Ghosh U K, Garg Parul, Tomar Geetika, Madan Molly, Bansal Rani
机构信息
Subharti Medical College, Meerut, India.
出版信息
J Obstet Gynaecol India. 2014 Jun;64(3):193-6. doi: 10.1007/s13224-013-0499-7. Epub 2014 Jan 4.
OBJECTIVE
To find the incidence of human papillomavirus (HPV) infection and cervical intraepithelial neoplasia (CIN) in pregnant women and compare Pap smear with the HPV DNA test in detecting HPV infection.
MATERIALS AND METHODS
Hundred antenatal women, irrespective of gestational age, were enrolled as subjects in this prospective pilot study for blood investigations, wet mount examination of cervical discharge, Pap smear, and high-risk HPV DNA detection of cervical scrape by PCR. Women showing abnormality in Pap smear and/or those who were high-risk HPV DNA positive were subjected to colposcopy.
RESULTS
The incidence of HPV-positive pregnant women was 18 %. Koilocytosis on Pap smear was observed in six women. Three high-risk HPV DNA-positive women showed changes consistent with CIN 1 on colposcopy.
CONCLUSIONS
The HPV DNA test is the most sensitive and reliable in detecting HPV infection as compared to Pap smear, but considering the cost of PCR, Pap smear screening of all antenatal women was recommended.
目的
了解孕妇人乳头瘤病毒（HPV）感染及宫颈上皮内瘤变（CIN）的发生率，并比较巴氏涂片与HPV DNA检测在检测HPV感染中的效果。
材料与方法
本前瞻性初步研究纳入100例孕妇，无论孕周大小，均作为研究对象进行血液检查、宫颈分泌物湿片检查、巴氏涂片以及通过聚合酶链反应（PCR）检测宫颈刮片的高危型HPV DNA。巴氏涂片显示异常和/或高危型HPV DNA阳性的女性接受阴道镜检查。
结果
HPV阳性孕妇的发生率为18%。6名女性巴氏涂片可见挖空细胞。3名高危型HPV DNA阳性女性阴道镜检查显示符合CIN 1的改变。
结论
与巴氏涂片相比，HPV DNA检测在检测HPV感染方面最为敏感和可靠，但考虑到PCR的成本，建议对所有孕妇进行巴氏涂片筛查。
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