Department of Obstetrics and Gynecology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555, USA.
Am J Obstet Gynecol. 2011 Mar;204(3):213.e1-6. doi: 10.1016/j.ajog.2010.10.909. Epub 2011 Jan 17.
We sought to evaluate the association between passive cigarette smoke exposure and cervical cytological abnormalities in a predominantly Hispanic sample.
Data were collected as part of a larger, ongoing randomized clinical trial. Inclusion criteria were met by 4403 Hispanic (73%) and non-Hispanic (27%) women between 18-55 years of age (mean = 30.14 ± 8.7). Analysis of variance and multivariate logistic regression determined the association between passive smoke exposure and Pap abnormality.
Passive smoke exposure was positively associated with having an abnormal Pap smear (odds ratio, 1.70; 95% confidence interval, 1.14-2.52) as was current active smoking (odds ratio 1.45; 95% confidence interval, 1.03-2.04). Neither effect was modified by ethnicity. Increasing hours per week of passive smoke exposure was associated with low-grade squamous intraepithelial lesion (P < .05).
Passive smoke exposure is an important independent risk factor for cytological abnormalities in Hispanic and non-Hispanic women. This study adds to the growing body of evidence of the dangers of passive smoke exposure.
我们旨在评估在以西班牙裔为主的人群中，被动吸烟与宫颈细胞学异常之间的关系。
数据是作为一项更大的、正在进行的随机临床试验的一部分收集的。4403 名年龄在 18-55 岁之间的西班牙裔（73%）和非西班牙裔（27%）女性（平均年龄为 30.14 ± 8.7）符合纳入标准。方差分析和多变量逻辑回归确定了被动吸烟暴露与巴氏异常之间的关联。
被动吸烟暴露与巴氏涂片异常呈正相关（优势比，1.70；95%置信区间，1.14-2.52），当前吸烟也是如此（优势比 1.45；95%置信区间，1.03-2.04）。这两种效应都不受种族的影响。每周被动吸烟暴露的小时数增加与低度鳞状上皮内病变（LSIL）相关（P <.05）。
被动吸烟暴露是西班牙裔和非西班牙裔女性细胞学异常的一个重要独立危险因素。这项研究增加了越来越多的被动吸烟暴露危害的证据。
