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Gene-Gene Interaction between LCE and CLEC16A Increases the Risk of Psoriasis in a Chinese Population.

作者信息

Wang Jianbo, Ding Yantao, Fan Xing, Zuo Xianbo, Wang Wen, Cheng Hui, Li Ping, Sun Liangdan, Yang Sen, Zhang Xuejun

机构信息

Institute of Dermatology, Department of Dermatology, No.1 Hospital, Anhui Medical University, Anhui, China.

Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, Hefei, Anhui, China.

出版信息

Ann Dermatol. 2014 Jun;26(3):421-3. doi: 10.5021/ad.2014.26.3.421. Epub 2014 Jun 12.

DOI:10.5021/ad.2014.26.3.421
PMID:24966655
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4069666/
Abstract
摘要

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Increased Risk of Psoriasis due to combined effect of HLA-Cw6 and LCE3 risk alleles in Indian population.印度人群中HLA - Cw6和LCE3风险等位基因的联合作用导致银屑病风险增加。
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本文引用的文献

1
The roles of cells and cytokines in the pathogenesis of psoriasis.细胞和细胞因子在银屑病发病机制中的作用。
Int J Dermatol. 2012 Apr;51(4):389-95; quiz 395-8. doi: 10.1111/j.1365-4632.2011.05154.x.
2
Shared genetic factors may not explain the raised risk of comorbid inflammatory diseases in multiple sclerosis.共享的遗传因素可能无法解释多发性硬化症中并发炎症性疾病风险增加的原因。
Mult Scler. 2012 Oct;18(10):1430-6. doi: 10.1177/1352458512438240. Epub 2012 Mar 14.
3
TALE homeodomain proteins regulate site-specific terminal differentiation, LCE genes and epidermal barrier.TALE 同源结构域蛋白调节特定部位的终末分化、LCE 基因和表皮屏障。
J Cell Sci. 2011 May 15;124(Pt 10):1681-90. doi: 10.1242/jcs.077552. Epub 2011 Apr 21.
4
Psoriasis risk genes of the late cornified envelope-3 group are distinctly expressed compared with genes of other LCE groups.与其他 LCE 组的基因相比,晚期角质化包膜 3 组的银屑病风险基因明显表达。
Am J Pathol. 2011 Apr;178(4):1470-7. doi: 10.1016/j.ajpath.2010.12.017.
5
Variants in MHC, LCE and IL12B have epistatic effects on psoriasis risk in Chinese population.MHC、LCE 和 IL12B 中的变异与中国人银屑病发病风险存在上位效应。
J Dermatol Sci. 2011 Feb;61(2):124-8. doi: 10.1016/j.jdermsci.2010.12.001. Epub 2010 Dec 14.
6
Meta-analysis confirms the LCE3C_LCE3B deletion as a risk factor for psoriasis in several ethnic groups and finds interaction with HLA-Cw6.荟萃分析证实 LCE3C_LCE3B 缺失是多个族群罹患银屑病的风险因素,并发现与 HLA-Cw6 存在相互作用。
J Invest Dermatol. 2011 May;131(5):1105-9. doi: 10.1038/jid.2010.350. Epub 2010 Nov 25.
7
Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21.银屑病全基因组关联研究确定了位于1q21的LCE基因簇内的易感变异。
Nat Genet. 2009 Feb;41(2):205-10. doi: 10.1038/ng.310. Epub 2009 Jan 25.
8
Deletion of the late cornified envelope LCE3B and LCE3C genes as a susceptibility factor for psoriasis.晚期角质包膜LCE3B和LCE3C基因缺失作为银屑病的一个易感因素。
Nat Genet. 2009 Feb;41(2):211-5. doi: 10.1038/ng.313. Epub 2009 Jan 25.
9
The expanding genetic overlap between multiple sclerosis and type I diabetes.多发性硬化症与I型糖尿病之间不断扩大的基因重叠。
Genes Immun. 2009 Jan;10(1):11-4. doi: 10.1038/gene.2008.83. Epub 2008 Nov 6.
10
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.通过全基因组分析得出的1型糖尿病四个新染色体区域的强关联。
Nat Genet. 2007 Jul;39(7):857-64. doi: 10.1038/ng2068. Epub 2007 Jun 6.