National Key Discipline of Pediatrics, Ministry of Education and Department of Endocrinology, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China.
Int J Endocrinol. 2012;2012:245384. doi: 10.1155/2012/245384. Epub 2012 Jun 20.
Objective. The CLEC16A gene is related to the genetic susceptibility to T1DM with racial variability. This study investigated the association between CLEC16A gene polymorphisms and T1DM in Chinese children. Methods. 131 Chinese children with T1DM were selected for study, and 121 healthy adult blood donors were selected as normal controls. PCR and mass spectrometry was used to study the distributions of 17 CLEC16A alleles in patients and controls. The relationship between CLEC16A gene polymorphisms and T1DM was studied. Results. The distributions of two polymorphisms (rs12921922, rs12931878) of CLEC16A in T1DM and healthy controls were significantly different, while the distributions of other CLEC16A polymorphisms show no significant differences. The alleles of rs12921922 are C and T. The frequency of the T allele was significantly increased in patients versus healthy controls. The alleles of rs12931878 are A and C. The frequencies of the A allele are significantly increased in T1DM patients versus healthy controls. Conclusion. Two polymorphisms in the CLEC16A gene correlate with increased susceptibility to T1DM in Chinese children, revealing that it was another new gene that correlates with susceptibility to T1DM in multiple populations.
CLEC16A 基因与 T1DM 的遗传易感性有关，且具有种族变异性。本研究旨在探讨 CLEC16A 基因多态性与中国儿童 T1DM 之间的关系。
选择 131 例 T1DM 患儿作为研究对象，121 例健康成人献血者作为正常对照。采用 PCR 和质谱技术研究患者和对照组中 17 个 CLEC16A 等位基因的分布。研究 CLEC16A 基因多态性与 T1DM 的关系。
CLEC16A 的两个多态性(rs12921922、rs12931878)在 T1DM 和健康对照组中的分布差异有统计学意义，而其他 CLEC16A 多态性的分布差异无统计学意义。rs12921922 的等位基因为 C 和 T。T 等位基因在患者中的频率明显高于健康对照组。rs12931878 的等位基因为 A 和 C。A 等位基因在 T1DM 患者中的频率明显高于健康对照组。
CLEC16A 基因的两个多态性与中国儿童 T1DM 的易感性增加相关，表明它是与多种人群 T1DM 易感性相关的另一个新基因。
