An endogenous inhibitor of the ADP-ribosylation of GTP-binding proteins by pertussis toxin is present in bovine brain.
作者信息
Hara-Yokoyama M, Furuyama S
机构信息
Department of Physiology, Nihon University School of Dentistry at Matsudo, Chiba, Japan.
出版信息
Biochem Biophys Res Commun. 1989 Apr 14;160(1):67-71. doi: 10.1016/0006-291x(89)91621-5.
PMID:2496691
Abstract
The ADP-ribosylation of GTP-binding proteins (G-proteins) catalyzed by pertussis toxin was inhibited by endogenous inhibitor activity in the membrane extract of bovine brain. Most of the activity appeared in the fractions eluted from a DEAE-Sephacel column by 0.5 M NaCl. The activity was heat-stable and sensitive to pronase K. The results suggest the presence of an endogenous inhibitor of pertussis toxin in bovine brain.
摘要
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