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An endogenous inhibitor of the ADP-ribosylation of GTP-binding proteins by pertussis toxin is present in bovine brain.

作者信息

Hara-Yokoyama M, Furuyama S

机构信息

Department of Physiology, Nihon University School of Dentistry at Matsudo, Chiba, Japan.

出版信息

Biochem Biophys Res Commun. 1989 Apr 14;160(1):67-71. doi: 10.1016/0006-291x(89)91621-5.

DOI:10.1016/0006-291x(89)91621-5
PMID:2496691
Abstract

The ADP-ribosylation of GTP-binding proteins (G-proteins) catalyzed by pertussis toxin was inhibited by endogenous inhibitor activity in the membrane extract of bovine brain. Most of the activity appeared in the fractions eluted from a DEAE-Sephacel column by 0.5 M NaCl. The activity was heat-stable and sensitive to pronase K. The results suggest the presence of an endogenous inhibitor of pertussis toxin in bovine brain.

摘要

相似文献

1
An endogenous inhibitor of the ADP-ribosylation of GTP-binding proteins by pertussis toxin is present in bovine brain.
Biochem Biophys Res Commun. 1989 Apr 14;160(1):67-71. doi: 10.1016/0006-291x(89)91621-5.
2
Endogenous inhibitor of the ADP-ribosylation of (a) G-protein(s) as catalyzed by pertussis toxin is present in rat liver.大鼠肝脏中存在百日咳毒素催化的（一种）G蛋白（的）ADP核糖基化的内源性抑制剂。
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3
Two guanine nucleotide-binding proteins in rat brain serving as the specific substrate of islet-activating protein, pertussis toxin. Interaction of the alpha-subunits with beta gamma-subunits in development of their biological activities.大鼠脑中作为百日咳毒素（胰岛激活蛋白）特异性底物的两种鸟嘌呤核苷酸结合蛋白。α亚基与βγ亚基在其生物活性发展过程中的相互作用。
J Biol Chem. 1986 Jun 25;261(18):8182-91.
4
GTP-binding proteins in etiolated epicotyls of Pisum sativum (Alaska) seedlings.豌豆（阿拉斯加）幼苗黄化上胚轴中的GTP结合蛋白
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Spermatozoa contain a guanine nucleotide-binding protein ADP-ribosylated by pertussis toxin.精子含有一种被百日咳毒素进行ADP核糖基化修饰的鸟嘌呤核苷酸结合蛋白。
Biochem Biophys Res Commun. 1986 Jul 31;138(2):728-34. doi: 10.1016/s0006-291x(86)80557-5.
6
ADP-ribosylation of the bovine brain rho protein by botulinum toxin type C1.肉毒杆菌毒素C1型对牛脑rho蛋白的ADP核糖基化作用。
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7
Mechanisms for inhibition of the catalytic activity of adenylate cyclase by the guanine nucleotide-binding proteins serving as the substrate of islet-activating protein, pertussis toxin.作为百日咳毒素（胰岛激活蛋白）底物的鸟嘌呤核苷酸结合蛋白对腺苷酸环化酶催化活性的抑制机制。
J Biol Chem. 1986 Apr 15;261(11):5215-21.
8
Conformations of the alpha 39, alpha 41, and beta.gamma components of brain guanine nucleotide-binding proteins. Analysis by limited proteolysis.脑鸟嘌呤核苷酸结合蛋白α39、α41和βγ亚基的构象。有限蛋白酶解分析。
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9
Subunit interactions of native and ADP-ribosylated alpha 39 and alpha 41, two guanine nucleotide-binding proteins from bovine cerebral cortex.来自牛大脑皮层的两种鸟嘌呤核苷酸结合蛋白——天然型及 ADP 核糖基化的α39 和α41 的亚基相互作用
J Biol Chem. 1986 Jan 25;261(3):1105-10.
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Partial characterization of GTP-binding proteins in Neurospora.粗糙脉孢菌中GTP结合蛋白的部分特性分析
Biochem Biophys Res Commun. 1987 Aug 14;146(3):1178-83. doi: 10.1016/0006-291x(87)90772-8.

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