Hara-Yokoyama M, Furuyama S
Department of Physiology, Nihon University School of Dentistry at Matsudo, Japan.
FEBS Lett. 1988 Jul 4;234(1):27-30. doi: 10.1016/0014-5793(88)81295-x.
The inhibitor activity of the ADP-ribosylation of (a) G-protein(s) as catalyzed by pertussis toxin was found in the membrane extract of rat liver. The inhibitor activity was found in the fractions of DEAE-Sephacel column chromatography at 50-120 mM NaCl. The inhibitor activity is not due to the degradation of NAD nor to the reverse reaction of pertussis toxin (removal of incorporated ADP-ribose). The present result suggests the presence of an endogenous inhibitor of the ADP-ribosylation reaction of (a) G-protein(s).
在大鼠肝脏的膜提取物中发现了由百日咳毒素催化的（一种）G蛋白的ADP核糖基化的抑制活性。在DEAE-葡聚糖凝胶柱色谱中50-120 mM NaCl的组分中发现了该抑制活性。该抑制活性不是由于NAD的降解，也不是由于百日咳毒素的逆反应（去除掺入的ADP-核糖）。目前的结果表明存在一种内源性的（一种）G蛋白的ADP核糖基化反应抑制剂。
Zotero 插件