Del Gobbo Alessandro, Fiori Stefano, Gaudioso Gabriella, Bonaparte Eleonora, Tabano Silvia, Palleschi Alessandro, Bosari Silvano, Ferrero Stefano
Division of Pathology, Fondazione IRCCS "Ca' Granda" - Ospedale Maggiore Policlinico and University of Milan Medical School Italy.
Department of Clinical/Surgical Pathophysiology and Organ Transplant, University of Milan Medical School and Division of Pathology, Fondazione IRCCS "Ca' Granda" - Ospedale Maggiore Policlinico Italy.
Int J Clin Exp Pathol. 2014 Apr 15;7(5):2484-9. eCollection 2014.
The coexistence of mesothelioma and other primary malignancies has been previously reported in literature, but the finding of a pleural mesothelioma with a synchronous peritoneal mesothelioma has not been reported so far. We report a case of a 58-years-old woman that came to our attention for the incidental finding of an inguinal mass. Fine-needle biopsies of the mass and a thoracoscopy with pleural biopsies were performed, after imaging studies showed pleural thickenings suspicious for malignancy. Histological morphology and growth pattern were similar in both cases. Both tumors stained for calretinin, but only the pleural mesothelioma showed positivity for Wilms-Tumor 1 antibody. We tried to demonstrate with molecular biology techniques whether they were synchronous or one was the metastasis of the other, but our studies did not give informative results. The prognosis in this case is poor, and after 6 months the patient is still following a chemotherapy regimen, which is the only practicable approach given the extent of the disease.
间皮瘤与其他原发性恶性肿瘤并存的情况此前已有文献报道，但胸膜间皮瘤与同步发生的腹膜间皮瘤的病例迄今尚未见报道。我们报告一例58岁女性，因偶然发现腹股沟肿块而引起我们的注意。在影像学检查显示胸膜增厚可疑为恶性后，对肿块进行了细针穿刺活检，并进行了胸腔镜检查及胸膜活检。两例病例的组织学形态和生长模式相似。两种肿瘤均钙视网膜蛋白染色阳性，但仅胸膜间皮瘤对威尔姆斯瘤1抗体呈阳性。我们试图用分子生物学技术证明它们是同步发生的，还是其中一个是另一个的转移灶，但我们的研究未得出有意义的结果。该病例预后较差，6个月后患者仍在接受化疗方案，鉴于疾病的程度，这是唯一可行的方法。
