Li Peng, Zhou Houmin, Zhu Xinhong, Ma Guiliang, Liu Chao, Lin Bin, Mao Weizheng
Department of General Surgery, Qingdao Municipal Hospital, Qingdao University Medical College Qingdao, China.
Department of International Clinic, Qingdao Municipal Hospital, Qingdao University Medical College Qingdao, China.
Int J Clin Exp Pathol. 2014 Apr 15;7(5):2565-70. eCollection 2014.
NEDD9, a member of Crk-associated substrate (CAS) family, is highly expressed in multiple cancer types and involved cancer cell adhesion, migration, invasion. The prognostic value of NEDD9 has not been evaluated before. The aim of this study was to evaluate the association between NEDD9 expression and survival in colorectal cancer (CRC) patients. NEDD9 expression was analyzed by immunohistochemistry in 92 patients with CRC. Patients were followed-up annually by telephone or at outpatient clinic. The results revealed that high expression of NEDD9 in 68/92 CRC samples, compared with 12/92 normal tissues (P<0.01). Correlation analysis showed high level of expression of NEDD9 was significantly correlated with advanced TNM stage (P=0.014), pT grade (P=0.009), pN (P=0.013) and pM status (P=0.047). Patients with a higher NEDD9 expression had a significantly shorter overall survival (OS) (P<0.01). The multivariate analysis revealed that NEDD9 expression could serve as an independent predictive factor of OS. Our finding demonstrated the potential value of NEDD9 expression level as a prognostic molecular marker and a target for new therapies for CRC patients.
NEDD9是Crk相关底物（CAS）家族的成员之一，在多种癌症类型中高表达，并参与癌细胞的黏附、迁移和侵袭。此前尚未评估过NEDD9的预后价值。本研究的目的是评估NEDD9表达与结直肠癌（CRC）患者生存率之间的关联。通过免疫组织化学分析了92例CRC患者的NEDD9表达情况。每年通过电话或门诊对患者进行随访。结果显示，68/92例CRC样本中NEDD9高表达，而正常组织中为12/92例（P<0.01）。相关性分析表明，NEDD9的高表达水平与晚期TNM分期（P=0.014）、pT分级（P=0.009）、pN（P=0.013）和pM状态（P=0.047）显著相关。NEDD9表达较高的患者总生存期（OS）显著缩短（P<0.01）。多变量分析显示，NEDD9表达可作为OS的独立预测因素。我们的研究结果证明了NEDD9表达水平作为CRC患者预后分子标志物和新治疗靶点的潜在价值。
