Zhao Zhi, Han Fang-Hai, Yang Shi-Bin, Hua Li-Xin, Wu Jian-Hai, Zhan Wen-Hua
Zhi Zhao, Fang-Hai Han, Shi-Bin Yang, Li-Xin Hua, Jian-Hai Wu, Wen-Hua Zhan, Department of Gastrointestinal Surgery, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China.
World J Gastroenterol. 2015 Jan 28;21(4):1140-7. doi: 10.3748/wjg.v21.i4.1140.
To investigate the clinicopathological significance and prognostic value of caveolin-1 (CAV-1) in both tumor and stromal cells in colorectal cancer (CRC).
A total of 178 patients with CRC were included in this study. The correlation between CAV-1 expression and clinicopathologic features and survival was studied.
CAV-1 expression was detected in tumor and stromal cells. The expression of stromal CAV-1 was closely associated with histological type (P=0.022), pathologic tumor-node-metastasis stage (P=0.047), pathologic N stage (P=0.035) and recurrence (P=0.000). However, tumor cell CAV-1 did not show any correlation with clinical parameters. Additionally, the loss of stromal CAV-1 expression was associated with shorter disease-free survival (P=0.000) and overall survival (P=0.000). Multivariate analysis revealed that the loss of stromal CAV-1 expression was an independent prognostic factor for both overall survival (P=0.014) and disease-free survival (P=0.006).
The loss of stromal CAV-1 expression in CRC was associated with poor prognosis and could be a prognostic factor for CRC patients.
探讨小窝蛋白-1（CAV-1）在结直肠癌（CRC）肿瘤细胞和基质细胞中的临床病理意义及预后价值。
本研究共纳入178例CRC患者。研究CAV-1表达与临床病理特征及生存情况之间的相关性。
在肿瘤细胞和基质细胞中均检测到CAV-1表达。基质CAV-1的表达与组织学类型（P=0.022）、病理肿瘤-淋巴结-转移分期（P=0.047）、病理N分期（P=0.035）及复发（P=0.000）密切相关。然而，肿瘤细胞CAV-1与临床参数无任何相关性。此外，基质CAV-1表达缺失与无病生存期缩短（P=0.000）和总生存期缩短（P=0.000）相关。多因素分析显示，基质CAV-1表达缺失是总生存期（P=0.014）和无病生存期（P=0.006）的独立预后因素。
CRC中基质CAV-1表达缺失与预后不良相关，可能是CRC患者的一个预后因素。
