Hassan Wael, Nishi Junko, Tomiyasu Shinjiro, Urakado Tadahito, Haraoka Katsuki, Yamanaka Tuyoshi, Fujiyama Shigetoshi, Ito Takaaki
Department of Pathology and Experimental Medicine, Kumamoto University, Graduate School of Medical Sciences Kumamoto, Japan ; Department of Pathology, Faculty of Medicine, Suez Canal University Ismailia, Egypt.
Department of Radiology, Kumamoto Shinto General Hospital Kumamoto, Japan.
Int J Clin Exp Pathol. 2014 Apr 15;7(5):2647-53. eCollection 2014.
Myoepithelial carcinoma is a well-known tumor of salivary gland, representing 1% of all salivary gland tumors. They have also been reported in other sites as skin/soft tissue, breast and lung. This paper reports a rare case of primary myoepithelial carcinoma in the liver, as well as discusses the findings of immunohistochemistry. The clinical manifestations, imaging characteristics, and histopathological changes of myoepithelial carcinoma in this case were described. The patient was a 33 years old female presented with a cystic tumor in the right lobe of the liver. As the liver tumor increased in size within six months, malignant neoplasm was suspected and thus anterior hepatic segmentectomy was performed. The mass composed of glandular-like structures and trabecular sheets of spindled shaped cells and epithelioid cells which were positive for myoepithelial markers. The tumor recurred within one year, in the left lobe of the liver and partial left lobe lobectomy was performed. The tumor resected showed similar histology to the primary tumor. Three months later, another recurrence was noted for which radiofrequency ablation was performed. This report presents a recurrent case of myoepithelial carcinoma in the liver and suggests the possibility of biliary origin of such tumor.
肌上皮癌是一种众所周知的涎腺肿瘤，占所有涎腺肿瘤的1%。也有报道称其发生于其他部位，如皮肤/软组织、乳腺和肺。本文报告了一例罕见的肝脏原发性肌上皮癌病例，并讨论了免疫组织化学结果。描述了该病例中肌上皮癌的临床表现、影像学特征和组织病理学变化。患者为一名33岁女性，肝脏右叶出现一个囊性肿瘤。由于肝脏肿瘤在6个月内增大，怀疑为恶性肿瘤，因此进行了肝前段切除术。肿块由腺管状结构以及梭形细胞和上皮样细胞的小梁状薄片组成，肌上皮标志物呈阳性。肿瘤在一年内复发，位于肝脏左叶，遂进行了左肝部分切除术。切除的肿瘤显示出与原发肿瘤相似的组织学特征。3个月后，发现再次复发，进行了射频消融治疗。本报告呈现了一例肝脏肌上皮癌复发病例，并提示了此类肿瘤可能起源于胆管。
