Lee Jeffrey R, Georgi David E, Wang Beverly Y
Department of Pathology, Medical College of Georgia, Augusta, GA 30912, USA.
Ann Diagn Pathol. 2007 Jun;11(3):190-8. doi: 10.1016/j.anndiagpath.2006.04.004.
Myoepithelial tumors of the soft tissues have only recently been described. Two cases of lower extremity malignant myoepithelial tumors are reported. One case of malignant mixed tumor overlying the gastrocnemius muscle was treated with wide local excision, but metastasized to regional lymph nodes 14 months after surgical excision. One patient with malignant myoepithelioma of the right lower leg was treated with limb amputation and is alive without disease at 46 months. A review of the literature discloses 120 additional cases of soft tissue myoepithelial tumors, 102 of which are myoepitheliomas and 18 are mixed tumors. Thirty-seven percent of the myoepitheliomas met the criteria for malignancy, and 33% of the mixed tumors were malignant. Of these, 30% had locally recurrent disease and 32% developed metastatic disease. Treatment benefit from chemotherapy and radiation therapy is unclear.
软组织肌上皮肿瘤直到最近才被描述。本文报告了两例下肢恶性肌上皮肿瘤。1例位于腓肠肌上方的恶性混合瘤接受了广泛局部切除，但术后14个月出现区域淋巴结转移。1例右小腿恶性肌上皮瘤患者接受了截肢治疗，术后46个月无病存活。文献回顾发现另外120例软组织肌上皮肿瘤，其中102例为肌上皮瘤，18例为混合瘤。37%的肌上皮瘤符合恶性标准，33%的混合瘤为恶性。其中，30%有局部复发，32%发生转移。化疗和放疗的治疗效果尚不清楚。
