评价庆大霉素治疗新生儿的尿酶。
Evaluation of urinary enzymes in newborns treated with gentamicin.
机构信息
Alborz Hospital, Social Security Organization, Karaj, Iran ; Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran.
Alborz Hospital, Social Security Organization, Karaj, Iran.
出版信息
Iran J Basic Med Sci. 2014 May;17(5):391-5.
OBJECTIVES
In recent years, there has been an increasing amount of study on early diagnosis of kidney injury through sensitive and specific biomarkers. We examined the practical applicability of the urinary levels of NAG (N-acetyl-β-D-glucosaminidase), AP (alkaline phosphatase), and LDH (lactate dehydrogenase) as renal dysfunction screening biomarkers in full and pre-term newborns treated with gentamicin.
MATERIALS AND METHODS
Fourteen pre-term and fifteen full-term newborns who received gentamicin for suspected infections were enrolled. Serum and urine specimens were obtained before the zero days and after gentamicin infusion on the 1st, 3rd, and 5th days of treatment.
RESULTS
In full-term newborns a significant increase in urinary NAG, LDH, AP after 5 days of gentamicin administration compared with control group was noted (P<0.05, P<0.001 and P<0.01; respectively).
CONCLUSION
Our findings indicate that urinary enzymes may be useful in full-term newborns as a non-invasive method for evaluation of tubular function.
目的
近年来，越来越多的研究致力于通过敏感和特异性生物标志物来实现早期肾损伤诊断。我们研究了尿 NAG（N-乙酰-β-D-氨基葡萄糖苷酶）、AP（碱性磷酸酶）和 LDH（乳酸脱氢酶）水平作为接受庆大霉素治疗的足月和早产儿肾功能筛查生物标志物的实际适用性。
材料与方法
本研究纳入了 14 例接受庆大霉素治疗疑似感染的早产儿和 15 例足月新生儿。在治疗前（第 0 天）和治疗第 1、3、5 天采集血清和尿液标本。
结果
与对照组相比，在接受庆大霉素治疗 5 天后，足月新生儿的尿 NAG、LDH 和 AP 显著升高（P<0.05，P<0.001 和 P<0.01；分别）。
结论
我们的研究结果表明，尿酶可能是评估足月新生儿肾小管功能的一种非侵入性方法。
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