Paracelsus Medical University, Institute of Experimental Neuroregeneration, Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Strubergasse 22, 5020 Salzburg, Austria.
Paracelsus Medical University, Institute of Molecular Regenerative Medicine, Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Strubergasse 22, 5020 Salzburg, Austria.
Neural Plast. 2014;2014:723915. doi: 10.1155/2014/723915. Epub 2014 May 22.
Speculations on the involvement of hippocampal neurogenesis, a form of neuronal plasticity, in the aetiology of depression and the mode of action of antidepressive therapies, started to arise more than a decade ago. But still, conclusive evidence that adult neurogenesis contributes to antidepressive effects of pharmacological and physical therapies has not been generated yet. This review revisits recent findings on the close relation between the mode(s) of action of electroconvulsive therapy (ECT), a powerful intervention used as second-line treatment of major depression disorders, and the neurogenic response to ECT. Following application of electroconvulsive shocks, intricate interactions between neurogenesis, angiogenesis, and microglia activation, the hypothalamic-pituitary-adrenal axis and the secretion of neurotrophic factors have been documented. Furthermore, considering the fact that neurogenesis strongly diminishes along aging, we investigated the response to electroconvulsive shocks in young as well as in aged cohorts of mice.
十多年前，人们开始推测海马神经发生（一种神经元可塑性形式）在抑郁症的发病机制和抗抑郁治疗的作用模式中的作用。但是，仍然没有确凿的证据表明成年神经发生有助于药物治疗和物理治疗的抗抑郁作用。这篇综述重新审视了最近的发现，即电惊厥疗法（ECT）的作用模式与电惊厥对神经发生的反应之间的密切关系，ECT 是一种用于治疗重度抑郁症的二线干预措施。在应用电惊厥冲击后，已经记录到神经发生、血管生成和小胶质细胞激活、下丘脑-垂体-肾上腺轴和神经营养因子分泌之间的复杂相互作用。此外，鉴于神经发生随着衰老而强烈减弱，我们研究了年轻和老年小鼠对电惊厥冲击的反应。
