用于快速检测急性肾损伤的新型生物标志物。
New biomarkers for the quick detection of acute kidney injury.
作者信息
Simsek Abdulmuttalip, Tugcu Volkan, Tasci Ali Ihsan
机构信息
Department of Urology, Bakırkoy Dr. Sadi Konuk Training and Research Hospital, Tevfik Saglam Street No. 11, Zuhuratbaba, 3400 Istanbul, Turkey.
出版信息
ISRN Nephrol. 2012 Nov 1;2013:394582. doi: 10.5402/2013/394582. eCollection 2013.
Abstract
Acute kidney injury (AKI) is a common and strong problem in the diagnosis of which based on measurement of BUN and serum creatinine. These traditional methods are not sensitive and specific for the diagnosis of AKI. AKI is associated with increased morbidity and mortality in critically ill patients and a quick detection is impossible with BUN and serum creatinine. A number of serum and urinary proteins have been identified that may messenger AKI prior to a rise in BUN and serum creatinine. New biomarkers of AKI, including NGAL, KIM-1, cystatin-C, IL-18, and L-FABP, are more favourable tests than creatinine which have been identified and studied in several experimental and clinical training. This paper will discuss some of these new biomarkers and their potential as useful signs of AKI. We searched the literature using PubMed and MEDLINE with acute kidney injury, urine, and serum new biomarkers and the articles were selected only from publication types in English.
摘要
急性肾损伤（AKI）是一种常见且严重的问题，其诊断基于血尿素氮（BUN）和血清肌酐的测定。这些传统方法对AKI的诊断并不敏感且缺乏特异性。AKI与危重症患者的发病率和死亡率增加相关，而仅依靠BUN和血清肌酐无法实现快速诊断。已鉴定出多种血清和尿液蛋白，它们可能在BUN和血清肌酐升高之前就预示着AKI。AKI的新生物标志物，包括中性粒细胞明胶酶相关脂质运载蛋白（NGAL）、肾损伤分子-1（KIM-1）、胱抑素-C、白细胞介素-18（IL-18）和肝型脂肪酸结合蛋白（L-FABP），比肌酐是更有利的检测指标，已在多项实验和临床研究中得到鉴定和研究。本文将讨论其中一些新生物标志物及其作为AKI有用指标的潜力。我们使用PubMed和MEDLINE检索了有关急性肾损伤、尿液和血清新生物标志物的文献，所选文章仅来自英文出版物类型。
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