Cesani María Florencia, Oyhenart Evelia Edith, Pucciarelli Héctor Mario
Instituto de Genética Veterinaria, Facultad de Ciencias Veterinarias, UNLP-CONICET, CCT La Plata, La Plata 1900, Argentina.
Instituto de Genética Veterinaria, Facultad de Ciencias Veterinarias, UNLP-CONICET, CCT La Plata, La Plata 1900, Argentina ; Cátedra de Antropología Biológica IV, Facultad de Ciencias Naturales y Museo, UNLP, La Plata 1900, Argentina.
ISRN Nutr. 2014 Jan 30;2014:453460. doi: 10.1155/2014/453460. eCollection 2014.
The aim of this paper was to analyze if intergenerational undernutrition causes growth retardation in weight and body length in two generations of rats and, if so, to assess whether the delay is cumulative. Male and female rats were assigned to one of the following groups: (1) control: they were fed ad libitum and constituted the parental generation (P), and (2) undernourished generations (F1 and F2): they were fed on 75% of the control diet. Animals were weighed and X-rayed every ten days from 20 to 100 days old in order to measure total body length. Also, body mass index was calculated. Data were processed by ANOVA and LSD post hoc tests. Impairment in weight, body length, and body mass index was found in both generations; nevertheless growth retardation was greater in F2, indicating a cumulative effect of nutritional stress. Sex differences were found, since the cumulative effect of generational undernutrition was greater and earlier in males than in females. It is concluded that when the undernutrition acts with constant intensity during several generations, the growth retardation is cumulative, indicating a negative secular trend.
本文旨在分析两代大鼠的代际营养不良是否会导致体重和体长生长迟缓，如果是，则评估这种迟缓是否具有累积性。将雄性和雌性大鼠分为以下几组：（1）对照组：自由采食，构成亲代（P）；（2）营养不良组（F1和F2）：喂食对照饮食的75%。在动物20至100日龄期间，每十天对其进行称重和X光检查，以测量体长。此外，还计算了体重指数。数据通过方差分析和LSD事后检验进行处理。两代大鼠均出现体重、体长和体重指数受损的情况；然而，F2代的生长迟缓更为严重，表明营养应激具有累积效应。发现了性别差异，因为代际营养不良的累积效应在雄性中比在雌性中更大且出现得更早。得出的结论是，当营养不良在几代人中以恒定强度作用时，生长迟缓是累积性的，表明存在负面的长期趋势。
