Marinozzi Franco, Bini Fabiano, Quintino Alessandro, Corcione Massimo, Marinozzi Andrea
Mechanical and Thermal Measurements Laboratory, Department of Mechanical and Aerospace Engineering, "Sapienza" University of Rome, Via Eudossiana, 18-00184 Rome, Italy.
Department of Astronautical, Electrical and Energetic Engineering, "Sapienza" University of Rome, Via Eudossiana, 18-00184 Rome, Italy.
Biomed Res Int. 2014;2014:796519. doi: 10.1155/2014/796519. Epub 2014 May 21.
We firstly measured the swelling of single trabeculae from human femur heads during water imbibition. Since the swelling is caused by water diffusing from external surfaces to the core of the sample, by measuring the sample swelling over time, we obtained direct information about the transport of fluids through the intimate constituents of bone, where the mineralization process takes place. We developed an apparatus to measure the free expansion of the tissue during the imbibition. In particular, we measured the swelling along three natural axes (length L, width W, and thickness T) of plate-like trabeculae. For this aim, we developed a 3D analytical model of the water uptake by the sample that was performed according to Fickian transport mechanism. The results were then utilized to predict the swelling over time along the three sample directions (L, W, T) and the apparent diffusion coefficients D T, D W, and D L.
我们首先测量了人股骨头单个小梁在吸水过程中的肿胀情况。由于肿胀是由水从样品外表面扩散到核心引起的，通过测量样品随时间的肿胀情况，我们获得了有关流体在发生矿化过程的骨的紧密成分中传输的直接信息。我们开发了一种装置来测量吸水过程中组织的自由膨胀。特别是，我们测量了板状小梁沿三个自然轴（长度L、宽度W和厚度T）的肿胀情况。为此，我们根据菲克传输机制建立了样品吸水的三维分析模型。然后利用这些结果预测样品沿三个方向（L、W、T）随时间的肿胀情况以及表观扩散系数DT、DW和DL。
