脑沉默调节蛋白对哺乳动物衰老和长寿的系统性调控
Systemic regulation of mammalian ageing and longevity by brain sirtuins.
作者信息
Satoh Akiko, Imai Shin-ichiro
机构信息
Department of Developmental Biology, Washington University School of Medicine, Campus Box 8103, 660 South Euclid Avenue, St Louis, Missouri 63110, USA.
出版信息
Nat Commun. 2014 Jun 26;5:4211. doi: 10.1038/ncomms5211.
Abstract
Sirtuins regulate numerous important biological processes in mammals, including various age-associated pathophysiologies. However, whether sirtuins are critical to control ageing and longevity in mammals has been controversial. Recent studies have demonstrated critical roles of sirtuins in the brain, especially the hypothalamus, in governing multiple physiological functions. These data provide strong evidence that brain sirtuins regulate mammalian ageing and longevity at the organismal level.
摘要
沉默调节蛋白在哺乳动物中调节众多重要的生物学过程，包括各种与年龄相关的病理生理学过程。然而，沉默调节蛋白对于控制哺乳动物的衰老和寿命是否至关重要一直存在争议。最近的研究表明，沉默调节蛋白在大脑，尤其是下丘脑，在调控多种生理功能方面发挥着关键作用。这些数据提供了强有力的证据，证明大脑中的沉默调节蛋白在机体水平上调节哺乳动物的衰老和寿命。
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