Forbes Thomas P, Sisco Edward
National Institute of Standards and Technology , Materials Measurement Science Division, Gaithersburg, Maryland 20899, United States.
Anal Chem. 2014 Aug 5;86(15):7788-97. doi: 10.1021/ac501718j. Epub 2014 Jul 14.
We demonstrate the coupling of desorption electro-flow focusing ionization (DEFFI) with in-source collision induced dissociation (CID) for the mass spectrometric (MS) detection and imaging of explosive device components, including both inorganic and organic explosives and energetic materials. We utilize in-source CID to enhance ion collisions with atmospheric gas, thereby reducing adducts and minimizing organic contaminants. Optimization of the MS signal response as a function of in-source CID potential demonstrated contrasting trends for the detection of inorganic and organic explosive device components. DEFFI-MS and in-source CID enabled isotopic and molecular speciation of inorganic components, providing further physicochemical information. The developed system facilitated the direct detection and chemical mapping of trace analytes collected with Nomex swabs and spatially resolved distributions within artificial fingerprints from forensic lift tape. The results presented here provide the forensic and security sectors a powerful tool for the detection, chemical imaging, and inorganic speciation of explosives device signatures.
我们展示了解吸电流聚焦电离（DEFFI）与源内碰撞诱导解离（CID）的耦合，用于质谱（MS）检测和成像爆炸装置组件，包括无机和有机炸药以及含能材料。我们利用源内CID增强离子与大气气体的碰撞，从而减少加合物并使有机污染物最小化。作为源内CID电位函数的MS信号响应优化显示，无机和有机爆炸装置组件的检测呈现出对比趋势。DEFFI-MS和源内CID实现了无机组分的同位素和分子形态分析，提供了更多的物理化学信息。所开发的系统有助于直接检测和化学映射用Nomex拭子收集的痕量分析物，以及法医提取胶带人工指纹内的空间分辨分布。此处呈现的结果为法医和安全部门提供了一个强大的工具，用于检测、化学成像和爆炸装置特征的无机组分分析。
