George Susan R, Kern Andras, Smith Roy G, Franco Rafael
Departments of Medicine and Pharmacology, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada.
Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, FL, USA.
Prog Brain Res. 2014;211:183-200. doi: 10.1016/B978-0-444-63425-2.00008-8.
Dopamine neurotransmission is traditionally accepted as occurring through the five dopamine receptors that transduce its signal. Recent evidence has demonstrated that the range of physiologically relevant dopamine signaling complexes is greatly expanded by the ability of dopamine receptors to interact with other dopamine receptors and with receptors of other endogenous signaling ligands. These novel heteromeric complexes have functional properties distinct from the component receptors or are able to modulate the canonical signaling and function of the cognate receptors. These dopamine receptor heteromers provide new insight into physiological mechanisms and pathophysiological processes involving dopamine.
传统上认为多巴胺神经传递是通过五种转导其信号的多巴胺受体发生的。最近的证据表明，生理相关的多巴胺信号复合物的范围因多巴胺受体与其他多巴胺受体以及其他内源性信号配体的受体相互作用的能力而大大扩展。这些新型异源复合物具有与组成受体不同的功能特性，或者能够调节同源受体的经典信号传导和功能。这些多巴胺受体异聚体为涉及多巴胺的生理机制和病理生理过程提供了新的见解。
