Jørgensen M B, Deckert J, Wright D C, Gehlert D R
Experimental Therapeutics Branch, NINDS, Bethesda, MD 20892.
Brain Res. 1989 Apr 10;484(1-2):393-8. doi: 10.1016/0006-8993(89)90388-0.
The relative levels of c-fos mRNA in individual neurons of the hippocampal formation of rats is dramatically increased following 20 min of cerebral ischemia induced by 4-vessel occlusion. After 24 h of recirculation, a number of scattered neurons in the dentate hilus became hybridization positive. This effect appeared to peak between 24 and 48 h. A few neurons in the pyramidal cell layer of CA1 expressed c-fos as early as 24 h, but the most intense labeling in this region was seen at 72 h of recirculation. These results correlate well with the known distribution of delayed ischemic necrosis in the brain.
四动脉闭塞诱导大鼠脑缺血20分钟后，海马结构单个神经元中c-fos mRNA的相对水平显著升高。再灌注24小时后，齿状回门区出现一些散在的杂交阳性神经元。这种效应似乎在24至48小时达到峰值。CA1锥体细胞层的少数神经元早在24小时就表达c-fos，但在再灌注72小时时该区域的标记最为强烈。这些结果与脑中已知的延迟性缺血性坏死分布密切相关。
