Emami Zeydi Amir, Jannati Yadollah, Darvishi Khezri Hadi, Gholipour Baradari Afshin, Espahbodi Fatemeh, Lesani Mojgan, Yaghoubi Tahereh
Department of Nursing, Islamic Azad University, Sari Branch, Sari, Iran.
Saudi J Kidney Dis Transpl. 2014 Jul;25(4):750-5. doi: 10.4103/1319-2442.134962.
Poor sleep quality is a common problem that can potentially predict mortality risk and quality of life in hemodialysis (HD) patients. Also, inflammation is a common feature in HD patients. To determine sleep quality and its correlation with serum C-reactive protein (CRP) level in these patients, we studied 132 chronic HD patients in two university-affiliated teaching hospitals in Sari, Iran during September 2010. Pittsburgh Sleep Quality Index was employed to assess the sleep quality of the patients in addition to CRP, albumin, cholesterol, phosphorus and hemoglobin levels. There were 104 (78.7%) patients who suffered from poor sleep quality. A significant correlation was found between serum CRP level and the patients' sleep quality (P <0.05). There was also a significant correlation between sleep quality and serum phosphorus and albumin levels and body mass index (P <0.05). Furthermore, a significant positive correlation existed between the different components of sleep quality and CRP (P <0.05). We conclude that there is a correlation between decreased sleep quality in HD patients and elevated CRP levels, which may have therapeutic implications.
睡眠质量差是一个常见问题，它可能预示着血液透析（HD）患者的死亡风险和生活质量。此外，炎症是HD患者的一个常见特征。为了确定这些患者的睡眠质量及其与血清C反应蛋白（CRP）水平的相关性，我们于2010年9月在伊朗萨里的两家大学附属医院对132例慢性HD患者进行了研究。除了CRP、白蛋白、胆固醇、磷和血红蛋白水平外，还采用匹兹堡睡眠质量指数来评估患者的睡眠质量。有104例（78.7%）患者睡眠质量差。血清CRP水平与患者睡眠质量之间存在显著相关性（P<0.05）。睡眠质量与血清磷、白蛋白水平和体重指数之间也存在显著相关性（P<0.05）。此外，睡眠质量的不同组成部分与CRP之间存在显著正相关（P<0.05）。我们得出结论，HD患者睡眠质量下降与CRP水平升高之间存在相关性，这可能具有治疗意义。
