Haddad Mahbobeh, Tajbakhsh Ramin, Farajollahi Mehran, Qorbani Mostafa, Besharat Sima, Joshaghani Hamid Reza
Department of Medical Laboratory Sciences, Golestan Research Center of Gastroenterology and Hepatology (GRCGH), Golestan University of Medical Sciences, Gorgan, Iran.
Saudi J Kidney Dis Transpl. 2014 Jul;25(4):769-73. doi: 10.4103/1319-2442.134993.
Fetuin-A, a hepatic glycoprotein present in the circulation, is a potential inhibitor for systemic calcification. The main aim of this study was to evaluate the association between fetuin-A and other biochemical parameters as facilitator factors for developing atherosclerosis in hemodialysis (HD) patients. This case-control study was conducted on 44 HD patients undergoing treatment in 2012. Parathormone (i-PTH) and fetuin levels were performed by the enzyme-linked immunosorbent assay method, high-sensitivity C-reactive protein (hs-CRP) by chemiluminescence, low-density lipoprotein by direct enzymatic, calcium and albumin by colorimetric and phosphorous by ultraviolet (UV) methods. Chi-square was used for evaluating the association between variables and t-test was used for comparing the mean of the quantitative variables for the two groups. SPSS-16 software was used for data analysis and P-value less than 5% was considered as significant. Mean of serum fetuin level was 23.25 ± 4.90 ng/mL in HD patients and 32.92 ± 5.21 in the control group. Median of hs-CRP was 2.45 mg/dL in the patients and 1.00 mg/dL in the control group and i-PTH was 74.3 pg/mL in the patients and 7.30 pg/mL in the control group. The calcium-phosphorous product was 46.77 ± 14.22 mg/dL in the patient and 31.73 ± 6.48 mg/dL in the control group. A reverse significant association was found between fetuin-A and hs-CRP in this study. In this study, serum fetuin-A level in HD patients was lower than controls. Therefore, a low level of fetuin-A seems to be associated with atherosclerosis, inflammation and malnutrition.
胎球蛋白-A是一种存在于循环系统中的肝脏糖蛋白，是全身性钙化的潜在抑制剂。本研究的主要目的是评估胎球蛋白-A与其他生化参数之间的关联，这些参数作为血液透析（HD）患者动脉粥样硬化发展的促进因素。本病例对照研究于2012年对44例接受治疗的HD患者进行。采用酶联免疫吸附测定法检测甲状旁腺激素（i-PTH）和胎球蛋白水平，采用化学发光法检测高敏C反应蛋白（hs-CRP），采用直接酶法检测低密度脂蛋白，采用比色法检测钙和白蛋白，采用紫外（UV）法检测磷。采用卡方检验评估变量之间的关联，采用t检验比较两组定量变量的均值。使用SPSS-16软件进行数据分析，P值小于5%被认为具有显著性。HD患者血清胎球蛋白水平的均值为23.25±4.90 ng/mL，对照组为32.92±5.21 ng/mL。患者组hs-CRP的中位数为2.45 mg/dL，对照组为1.00 mg/dL；患者组i-PTH为74.3 pg/mL，对照组为7.30 pg/mL。患者组钙磷乘积为46.77±14.22 mg/dL，对照组为31.73±6.48 mg/dL。本研究发现胎球蛋白-A与hs-CRP之间存在显著的负相关。在本研究中，HD患者的血清胎球蛋白-A水平低于对照组。因此，低水平的胎球蛋白-A似乎与动脉粥样硬化、炎症和营养不良有关。
