Hashemi Javad, Joshaghani Hamid-Reza, Akaberi Arash, Hesari Zahra, Ghanbari Reza, Mohammadzadeh Mohsen, Golshan Ali-Reza
Emam Ali's Hospital, North Khorasan University of Medical Sciences, Bojnurd, Iran.
School of Paramedicine, Golestan University of Medical Sciences, Gorgan, Iran.
Arch Iran Med. 2017 Dec 1;20(12):752-755.
The strong correlation between vascular calcification and cardiovascular risk, which is a major cause of mortality in hemodialysis (HD) patients, has been well established. Fetuin-A is an inhibitor of vascular calcification, and pentraxin 3 (PTX3) is produced at the site of inflammation, which is associated with cardiovascular disease (CVD). The main purpose of this study was evaluating the correlation between fetuin-A and PTX3 with some biochemical parameters effective upon vascular calcification in HD patients.
We included 84 HD patients and 84 healthy controls matched for age, gender, and body mass index (BMI) in this study. Blood samples were drawn from all subjects and the serum levels of creatinine, urea, albumin, calcium (Ca), phosphorus (P), lowdensity lipoprotein cholesterol (LDL-C), parathyroid hormone, fetuin-A, high sensitive C-reactive protein, and PTX3 were measured by biochemical methods.
We found that the serum levels of PTX3, C-reactive protein (CRP), parathyroid hormone (PTH), Ca, and P in the patient group were significantly higher than the control group but the serum levels of fetuin-A and albumin were significantly lower in the patient group. Also, fetuin-A had a significant correlation with high sensitive CRP (hs-CRP) as well as duration of dialysis. In addition, it was shown that the correlation between PTX3 and PTH was significant only in the patient group.
In this study, increased PTX3 and decreased fetuin-A levels were observed in the HD patients. According to our results, these 2 parameters may potentially serve as suitable markers for inflammation and prediction of vascular complications in these patients.
血管钙化与心血管风险之间存在密切关联，而心血管风险是血液透析（HD）患者死亡的主要原因，这一点已得到充分证实。胎球蛋白-A是血管钙化的抑制剂，而五聚素3（PTX3）在炎症部位产生，炎症与心血管疾病（CVD）相关。本研究的主要目的是评估胎球蛋白-A和PTX3与一些对HD患者血管钙化有影响的生化参数之间的相关性。
本研究纳入了84例HD患者和84例年龄、性别及体重指数（BMI）相匹配的健康对照者。采集所有受试者的血样，采用生化方法测定血清肌酐、尿素、白蛋白、钙（Ca）、磷（P）、低密度脂蛋白胆固醇（LDL-C）、甲状旁腺激素、胎球蛋白-A、高敏C反应蛋白和PTX3的水平。
我们发现患者组的PTX3、C反应蛋白（CRP）、甲状旁腺激素（PTH）、Ca和P的血清水平显著高于对照组，但患者组的胎球蛋白-A和白蛋白血清水平显著较低。此外，胎球蛋白-A与高敏CRP（hs-CRP）以及透析时间存在显著相关性。另外，结果显示PTX3与PTH之间的相关性仅在患者组中显著。
在本研究中，观察到HD患者的PTX3水平升高而胎球蛋白-A水平降低。根据我们的结果，这两个参数可能潜在地作为这些患者炎症和血管并发症预测的合适标志物。
