Safa Javid, Noshad Hamid, Ansarin Khalil, Nikzad Alireza, Saleh Parviz, Ranjbar Abdolmohammad
Chronic Kidney Disease Research Center, Department of Nephrology, Sina Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.
Saudi J Kidney Dis Transpl. 2014 Jul;25(4):781-7. doi: 10.4103/1319-2442.135003.
End-stage renal disease (ESRD) is a complex illness that involves different organs including the lungs. We studied the pulmonary function tests, arterial blood gases (ABG) and plasma endothelin-1 (ET-1) levels to check whether there is any change in their levels after hemodialysis (HD) in patients with ESRD. In this cross-sectional study (from July 2009 to April 2010), 20 patients with ESRD were evaluated. ABG, spirometric parameters and plasma ET-1 were measured before and after HD in these patients. Student's t-test was performed to clarify the differences and Pearson's test was used for correlations. P <0.05 was considered statistically significant. Significant reduction was seen in oxygen saturation (O₂sat), partial pressure of carbon-dioxide (PaCO₂) and oxygen (PaO₂) after a HD session (P <0.001). Also, improvement was seen in all spirometric parameters except forced expiratory volume (FEV1)/forced vital capacity (FVC) after HD. Plasma ET-1 levels decreased significantly after HD. Mean ET-1 before HD was 6.88 + 5.81 pg/mL while it was 3.91 + 2.76 pg/mL after HD (P = 0.009). Based on the plasma levels of ET-1, the patients were divided into two groups. The mean level of ET-1 was higher in the first group. Significant increase was seen in spirometric parameters in the second group. Our study suggests that, in patients with ESRD, plasma ET-1 level is higher than in the normal population, and this is closely related to deterioration of pulmonary function tests. Significant reduction of plasma ET-1 may be an important factor in the improvement of spiro-metry parameters after HD.
终末期肾病（ESRD）是一种复杂疾病，累及包括肺在内的不同器官。我们研究了肺功能测试、动脉血气（ABG）和血浆内皮素 -1（ET -1）水平，以检查ESRD患者血液透析（HD）后这些指标水平是否有变化。在这项横断面研究（2009年7月至2010年4月）中，对20例ESRD患者进行了评估。在这些患者HD前后测量了ABG、肺量计参数和血浆ET -1。采用学生t检验来明确差异，Pearson检验用于相关性分析。P <0.05被认为具有统计学意义。HD治疗后，氧饱和度（O₂sat）、二氧化碳分压（PaCO₂）和氧分压（PaO₂）显著降低（P <0.001）。此外，HD后除用力呼气量（FEV1）/用力肺活量（FVC）外的所有肺量计参数均有改善。HD后血浆ET -1水平显著下降。HD前ET -1的平均值为6.88 + 5.81 pg/mL，而HD后为3.91 + 2.76 pg/mL（P = 0.009）。根据血浆ET -1水平，将患者分为两组。第一组ET -1的平均水平较高。第二组肺量计参数显著增加。我们的研究表明，ESRD患者的血浆ET -1水平高于正常人群，且这与肺功能测试的恶化密切相关。血浆ET -1的显著降低可能是HD后肺量计参数改善的一个重要因素。
