Lee Ha Young, Baek Jung Hwan, Yoo Hyunkyung, Kim Jae Kyun, Lim Myung Kwan, Chu Young Chae, Kang Young Hye, Lim Jae-Yol
Department of Radiology, University of Inha School of Medicine, Incheon, Korea.
Acta Cytol. 2014;58(4):330-4. doi: 10.1159/000363277. Epub 2014 Jun 26.
The purpose of this study was to determine whether the recommended waiting period of 3 months is necessary for repeat fine-needle aspiration biopsy (FNAB).
A retrospective review of 128 nodules from 126 patients with initial nondiagnostic (ND) results was performed for the period between January 2009 and December 2012. Demographic and clinical factors were recorded including age, sex, time interval between FNABs, and ultrasound (US) factors, i.e. nodule size, location, consistency, suspicious malignant findings and thyroiditis. The time interval was subdivided into </≥5, 10, 15 and 20 weeks after the initial FNAB. The effects on the nuclear atypia were analyzed using the Fisher exact test and the Mann-Whitney U test.
None of the demographic, clinical or US variables was significantly related to the atypical diagnosis of repeat FNAB. The time interval until repeat FNAB was also not related to the atypical diagnosis (p = 0.63, 0.57, 0.23 and 0.48 for 5, 10, 15 and 20 weeks, respectively).
The timing of repeat FNAB for thyroid nodules with previous ND results did not increase the nuclear atypia on repeat FNAB.
本研究旨在确定重复细针穿刺活检（FNAB）时推荐的3个月等待期是否必要。
对2009年1月至2012年12月期间126例患者的128个初次穿刺结果为非诊断性（ND）的结节进行回顾性研究。记录人口统计学和临床因素，包括年龄、性别、两次FNAB之间的时间间隔以及超声（US）因素，即结节大小、位置、质地、可疑恶性表现和甲状腺炎。时间间隔细分为初次FNAB后<5、≥5、10、15和20周。采用Fisher精确检验和Mann-Whitney U检验分析对核异型性的影响。
人口统计学、临床或超声变量均与重复FNAB的非典型诊断无显著相关性。直到重复FNAB的时间间隔也与非典型诊断无关（5、10、15和20周时p值分别为0.63、0.57、0.23和0.48）。
既往穿刺结果为ND的甲状腺结节重复FNAB的时间选择不会增加重复FNAB时的核异型性。
