Department of Endocrinology and Metabolism, Ankara Bilkent City Hospital, University of Health Sciences, Ankara, Turkey.
Department of Endocrinology and Metabolism, Ankara Bilkent City Hospital, Ankara, Turkey.
Endocrine. 2024 Dec;86(3):1065-1072. doi: 10.1007/s12020-024-03953-7. Epub 2024 Jul 10.
To determine whether early repeat fine needle aspiration biopsy (FNA) has an effect on adequate or atypia of undetermined significance (AUS) cytology rates in thyroid nodules with inadequate or AUS result in the first FNA.
Nodules of patients who underwent repeat biopsy due to insufficient or AUS cytology between 2019-2022 were included. Data of the patients and ultrasonographic, cytological and histopathological results of the nodules were recorded. Additionally, the time between the two biopsies was noted. The first was called "initial" and the second was called "rebiopsy". Five different paired groups were formed according to the time between two consecutive biopsies; before and after 1 month, 45 days, 2 months, 3 months, and 6 months. The groups were compared in terms of adequate and AUS cytological results.
We evaluated 1129 patients with 2187 nodules undergoing FNAB. After excluding nodules with one FNA result and/or missing data, 966 nodules of 628 patients who underwent FNA at least twice were included. Initial cytology was nondiagnostic (ND) in 665 (30.4%) and AUS in 301 (13.8%) nodules. The mean age of the patients was 52.0 ± 11.9 years, and the female sex ratio was 78.8% (n = 495). There were no differences in adequate or AUS rebiopsy results according to the different time interval groups (p > 0.05 for all). AUS result was statistically insignificantly more frequent in nodules with initially AUS nodules when rebiopsy was performed before 1 month in comparison to after 1 month (53.8%, 27.1%; p = 0.054). Accuracy of rebiopsy was also similar in the time intervals groups (p > 0.05 for all).
In patients with inadequate or AUS initial biopsy, the rate of adequate or AUS cytology results at rebiopsy did not vary with the timing of repeat biopsy indicating that there may be no need to wait 1 month for a repeat biopsy. In patients with suspicious nodules, biopsy might be repeated before 1 month.
确定在首次细针抽吸活检（FNA）结果为不充分或不确定意义的非典型（AUS）细胞学的甲状腺结节中，早期重复 FNA 是否会影响充分或 AUS 细胞学的比例。
纳入 2019 年至 2022 年间因首次 FNA 结果不充分或 AUS 而进行重复活检的患者的结节。记录患者的资料、结节的超声、细胞学和组织病理学结果，以及两次活检之间的时间。第一次称为“初始”，第二次称为“重复活检”。根据两次连续活检之间的时间，将患者分为五个不同的配对组：1 个月前和 1 个月后、45 天、2 个月、3 个月和 6 个月。比较两组充分和 AUS 细胞学结果。
我们评估了 1129 名患者的 2187 个结节进行了 FNAB。排除首次 FNA 结果为一个和/或数据缺失的结节后，纳入了至少进行了两次 FNA 的 628 名患者的 966 个结节。初始细胞学结果为不明确（ND）的有 665 个（30.4%），AUS 的有 301 个（13.8%）。患者的平均年龄为 52.0±11.9 岁，女性占 78.8%（n=495）。不同时间间隔组之间的充分或 AUS 重复活检结果没有差异（p>0.05 所有）。与 1 个月后相比，在首次 AUS 结节中，重复活检在 1 个月前进行时，AUS 结果更为频繁（53.8%，27.1%；p=0.054）。各时间间隔组的重复活检准确率也相似（p>0.05 所有）。
在首次 FNA 结果不充分或 AUS 的患者中，重复活检的充分或 AUS 细胞学结果的发生率与重复活检的时间无关，表明可能无需等待 1 个月再进行重复活检。在可疑结节患者中，可在 1 个月内重复进行活检。
