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[老年人癫痫。特殊临床特征与治疗策略]

[Epilepsy in the elderly. Special clinical features and treatment strategies].

作者信息

Tilz C

机构信息

Klinik für Neurologie, Krankenhaus Barmherzige Brüder Regensburg, Prüfeninger Str. 86, 93049, Regensburg, Deutschland,

出版信息

Internist (Berl). 2014 Jul;55(7):782-8. doi: 10.1007/s00108-014-3467-0.

Abstract

BACKGROUND

With increasing life expectancy, the incidence rate of epilepsy in the elderly has considerably increased in recent decades. This leads to new diagnostic and therapeutic challenges.

OBJECTIVES

Recognition of the special clinical features of epilepsy in the elderly is essential for diagnosis, therapy and prognosis. Special consideration is placed on comorbidity and drug interactions.

METHODS

The literature and new developments in this field are reviewed and discussed.

RESULTS

Epilepsy often presents in patients older than 60 years for the first time. The etiology of epilepsy in the elderly is heterogeneous with most belonging to symptomatic epilepsies that are associated with an underlying structural lesion of the brain. Epilepsy in the elderly is distinguished from that in other age groups by its clinical presentation. The treatment of seizures in the elderly is a particular challenge because not only due to comorbidity and co-medication but also because of metabolic changes in this age group.

CONCLUSION

Epilepsy in the elderly has diagnostic and therapeutic features that require careful clinical assessment and differentiated therapy.

摘要

背景

随着预期寿命的增加,近几十年来老年人癫痫的发病率显著上升。这带来了新的诊断和治疗挑战。

目的

认识老年人癫痫的特殊临床特征对于诊断、治疗和预后至关重要。需特别考虑合并症和药物相互作用。

方法

对该领域的文献和新进展进行综述和讨论。

结果

癫痫常首次出现在60岁以上的患者中。老年人癫痫的病因具有异质性,大多数属于症状性癫痫,与潜在的脑部结构病变有关。老年人癫痫在临床表现上与其他年龄组不同。老年人癫痫发作的治疗是一项特殊挑战,这不仅是由于合并症和联合用药,还因为该年龄组的代谢变化。

结论

老年人癫痫具有诊断和治疗特点,需要仔细的临床评估和个体化治疗。

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